Is an 8‐week regimen of glecaprevir/pibrentasvir sufficient for all hepatitis C virus infected patients in the real‐world experience?. Issue 7 (23rd November 2020)

• Record Type: Journal Article
• Authors: Zarębska‐Michaluk, Dorota; Jaroszewicz, Jerzy; Pabjan, Paweł; Łapiński, Tadeusz W; Mazur, Włodzimierz; Krygier, Rafał; Dybowska, Dorota; Halota, Waldemar; Pawłowska, Małgorzata; Janczewska, Ewa; Buczyńska, Iwona; Simon, Krzysztof; Dobracka, Beata; Citko, Jolanta; Laurans, Łukasz; Tudrujek‐Zdunek, Magdalena; Tomasiewicz, Krzysztof; Piekarska, Anna; Sitko, Marek; Białkowska‐Warzecha, Jolanta; Klapaczyński, Jakub; Sobala‐Szczygieł, Barbara; Horban, Andrzej; Berak, Hanna; Deroń, Zbigniew; Lorenc, Beata; Socha, Łukasz; Tronina, Olga; Flisiak, Robert
• Is Part Of: Journal of gastroenterology and hepatology. Volume 36:Issue 7(2021)
• Page Start: 1944
• Page End: 1952
• Publication Date: 2020-11-23
• Subjects: DAA -- Glecaprevir/pibrentasvir -- Hepatitis C virus; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.15337
• Languages: English
• ISSNs: 0815-9319

Abstract

Abstract: Background and Aims: The revolution of the antiviral treatment of hepatitis C virus (HCV) infection resulting in higher effectiveness came with the introduction of direct‐acting antivirals with pangenotypic regimens as a final touch. Among them, the combination of glecaprevir (GLE) and pibrentasvir (PIB) provides the opportunity for shortening therapy to 8 weeks in the majority of patients. Because of still insufficient evaluation of this regimen in the real‐world experience, our study aimed to assess the efficacy and safety of 8‐week GLE/PIB in chronic hepatitis C patients depending on liver fibrosis and genotype (GT). Methods: The analysis included patients who received GLE/PIB for 8 weeks selected from the EpiTer‐2 database, large retrospective national real‐world study evaluating antiviral treatment in 12 584 individuals in 22 Polish hepatology centers. Results: A total of 1034 patients with female predominance (52%) were enrolled in the analysis. The majority of them were treatment naïve (94%), presented liver fibrosis (F) of F0–F3 (92%), with the most common GT1b, followed by GT3. The overall sustained virologic response after exclusion of nonvirologic failures was achieved in 95.8% and 98%, respectively ( P = 0.19). In multivariate logistic regression HCV GT‐3 (beta = 0.07, P = 0.02) and HIV infection (beta = −0.14, P < 0.001) were independent predictors of nonresponse. Conclusions: We demonstrated high effectiveness of 8‐week GLE/PIB treatment in a non‐GT3 population irrespective of liver fibrosis stage. Comparable efficacy was achieved in non‐cirrhotic patients regardless of the genotype, including GT3 HCV.