Outcomes of Patients With Large Versus Small Bone Defects in Open Tibia Fractures Treated With an Intramedullary Nail: A Descriptive Analysis of a Multicenter Retrospective Study. Issue 8 (August 2022)

• Record Type: Journal Article
• Authors: Obremskey, William T.; Tornetta, Paul; Luly, Jason; Morshed, Saam; O'Toole, Robert V.; Hsu, Joseph R.; Mitchell, Stuart L.; Mackenzie, Ellen J.; Frey, Katherine P.; Castillo, Renan C.; Bosse, Michael J.; Scharfstein, Daniel O.
• Is Part Of: Journal of orthopaedic trauma. Volume 36:Issue 8(2022)
• Page Start: 388
• Page End: 393
• Publication Date: 2022-08
• Subjects: tibia -- fracture -- defect -- bone graft -- complications; Orthopedics -- Periodicals; Wounds and injuries -- Periodicals; Orthopedics -- Periodicals; Wounds and Injuries -- therapy -- Periodicals; Periodicals; 617.47044
• DOI: 10.1097/BOT.0000000000002337
• Languages: English
• ISSNs: 0890-5339

Abstract

Abstract : Supplemental Digital Content is Available in the Text. Abstract : Objectives: To compare outcomes in patients with open tibia shaft fractures based on defect size. Design: Retrospective review. Setting: Eighteen trauma centers. Population: The study included 132 patients with diaphyseal tibia bone defects >1 cm and ≥50% cortical loss treated with intramedullary nail. Outcomes: The primary outcome was number of secondary surgeries to promote healing (bone graft, revision fixation, or bone transport). Additional outcomes included occurrence of secondary surgeries (bone graft, infection, amputation, and flap failure) and proportion healed at one year. Results are compared by "radiographic apparent bone gap" of <2.5 or ≥2.5 cm. Results: The estimated conditional probability of bone grafting within one year given graft-free at 90 days was 44% and 47% in the <2.5 cm and ≥2.5 cm groups, respectively. An estimated infection risk of 14% was observed in both groups [adjusted hazard ratio (HR) 0.98, 95% confidence interval (CI): 0.33–2.92], estimated amputation risk was 9% (<2.5 cm) and 4% (≥2.5 cm) (unadjusted HR 0.66, 95% CI: 0.13–3.29), and estimated flap failure risk (among those with flaps) was 10% and 13%, respectively (unadjusted HR 1.71, 95% CI: 0.24–12.25). There was no appreciable difference in the proportion healed at one year between defect sizes [adjusted HR: 1.07 (95% CI, 0.63–1.82)]. Conclusions: Larger size bone defects were not associated with higher number of secondary procedures to promote healing or a lower overall one-year healing rate. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.