Utility of pre‐operative haemoglobin concentration to guide peri‐operative blood tests for hip and knee arthroplasty: A decision curve analysis. Issue 4 (11th May 2022)

• Record Type: Journal Article
• Authors: Dhiman, Paula; Gibbs, Victoria N.; Collins, Gary S.; Van Calster, Ben; Bakhishli, Gardash; Grammatopoulos, George; Price, Andrew J.; Taylor, Adrian; Murphy, Mike F.; Kendrick, Ben J. L.; Palmer, Antony J. R.
• Is Part Of: Transfusion medicine. Volume 32:Issue 4(2022)
• Page Start: 306
• Page End: 317
• Publication Date: 2022-05-11
• Subjects: blood transfusion -- decision curve analysis -- haemaglobin -- orthopaedics; Blood -- Transfusion -- Periodicals; 615.39
• DOI: 10.1111/tme.12873
• Languages: English
• ISSNs: 0958-7578

Abstract

Abstract: Objective: Assess the prognostic value of pre‐operative haemoglobin concentration (Hb) for identifying patients who develop severe post‐operative anaemia or require blood transfusion following primary total hip or knee, or unicompartmental knee arthroplasty (THA, TKA, UKA). Background: Pre‐operative group and save (G&S), and post‐operative Hb measurement may be unnecessary for many patients undergoing hip and knee arthroplasty provided individuals at greatest risk of severe post‐operative anaemia can be identified. Methods and Materials: Patients undergoing THA, TKA, or UKA between 2011 and 2018 were included. Outcomes were post‐operative Hb below 70 and 80 g/L, and peri‐operative blood transfusion. Logistic regression assessed the association between pre‐operative Hb and each outcome. Decision curve analysis compared strategies for selecting patients for G&S and post‐operative Hb measurement. Results: 10 015 THA, TKA and UKA procedures were performed in 8582 patients. The incidence of blood transfusion (4.5%) decreased during the study. Using procedure specific Hb thresholds to select patients for pre‐operative G&S and post‐operative Hb testing had a greater net benefit than selecting all patients, no patients, or patients with pre‐operative anaemia. Conclusions: Pre‐operative G&S and post‐operative Hb measurement may not be indicated for UKA or TKA when adopting restrictive transfusion thresholds, provided clinicians accept a 0.1% risk of patients developing severe undiagnosed post‐operative anaemia (Hb < 70 g/L). The decision to perform these blood tests for THA patients should be based on local institutional data and selection of acceptable risk thresholds.