Pancreas Cancer‐Associated Weight Loss. (27th December 2018)

• Record Type: Journal Article
• Authors: Hendifar, Andrew E.; Petzel, Maria Q.B.; Zimmers, Teresa A.; Denlinger, Crystal S.; Matrisian, Lynn M.; Picozzi, Vincent J.; Rahib, Lola
• Other Names: Hendifar Andrew investigator.; Tuli Richard investigator.; Wolpin Brian investigator.; Hidalgo Manuel investigator.; Ryan David investigator.; Hingorani Sunil investigator.; Chiorean Elena Gabriela investigator.; Coveler Andrew investigator.; O'Reilly Eileen investigator.; Balachandran Vinod investigator.; Simeone Diane investigator.; Lowy Andrew investigator.; Fanta Paul investigator.; Kurzrock Razelle investigator.; Reid Tony investigator.; Ko Andrew investigator.; Collisson Eric investigator.; Tempero Margaret investigator.; Kindler Hedy investigator.; George Thomas investigator.; Trevino Jose investigator.; Vonderheide Robert investigator.; Beatty Gregory investigator.; Picozzi Vincent investigator.; Mandelson Margaret investigator.; Wang‐Gillam Andrea investigator.; Hawkins William investigator.; Fleshman Julie investigator.; Hidalgo Manuel investigator.; Hingorani Sunil investigator.; Maitra Anirban investigator.; Manax Victoria investigator.; Matrisian Lynn investigator.; Picozzi Vincent investigator.; Simeone Diane investigator.;
• Is Part Of: Oncologist. Volume 24:Number 5(2019)
• Page Start: 691
• Page End: 701
• Publication Date: 2018-12-27
• Subjects: Pancreatic cancer -- Weight loss -- Cachexia -- Anorexia -- Malabsorption -- Supportive care; Oncology -- Periodicals; Tumors -- Periodicals; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Oncology; Tumors; Neoplasms; Electronic journals; Periodicals; Periodicals; 616.994
• DOI: 10.1634/theoncologist.2018-0266
• Languages: English
• ISSNs: 1083-7159

Abstract

Abstract: : Unintentional weight loss in patients with pancreatic cancer is highly prevalent and contributes to low therapeutic tolerance, reduced quality of life, and overall mortality. Weight loss in pancreatic cancer can be due to anorexia, malabsorption, and/or cachexia. Proper supportive care can stabilize or reverse weight loss in patients and improve outcomes. We review the literature on supportive care relevant to pancreatic cancer patients, and offer evidence‐based recommendations that include expert nutritional assessment, counseling, supportive measures to ensure adequate caloric intake, pancreatic enzyme supplementation, nutritional supplement replacement, orexigenic agents, and exercise. Pancreatic Cancer Action Network‐supported initiatives will spearhead the dissemination and adoption of these best supportive care practices. Abstract : This review highlights the etiology, assessment, and management of unintentional weight loss in patients with pancreatic cancer and provides recommendations for best supportive care.