Geraniol enhances peroxiredoxin‐1, and prevents isoproterenol‐induced oxidative stress and inflammation associated with myocardial infarction in experimental animal models. Issue 8 (24th May 2022)

• Record Type: Journal Article
• Authors: Zou, Gangqiang; Wan, Jia; Balupillai, Agilan; David, Ernest; Ranganathan, Babujanarthanam; Saravanan, Kalaimani
• Is Part Of: Journal of biochemical and molecular toxicology. Volume 36:Issue 8(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-24
• Subjects: antioxidants -- geraniol -- isoproterenol -- oxidative stress -- peroxiredoxin‐1; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Toxicology -- Periodicals; 574
• DOI: 10.1002/jbt.23098
• Languages: English
• ISSNs: 1095-6670

Abstract

Abstract: This study has explored the fact that geraniol prevents isoproterenol (ISO)‐induced oxidative stress and inflammation‐mediated myocardial infarction (MI) through enhanced expression of peroxiredoxin‐1 (Prdx‐1) in experimental animal models. The experimental strategies of MI were stimulated through the subcutaneous direction of ISO (85 mg/kg body weight) for 14 days. ISO‐directed models showed elevated heart rate levels and cardiac markers (serum creatine kinase [CK], serum CK‐myocardial band, serum C‐reactive proteins, and plasma homocysteine); increased cardiac‐troponins‐T, and troponin‐I levels in both serum and myocardium. Moreover, we perceived that a higher level of lipid peroxidation molecules (thiobarbituric acid reactive substances and lipid hydroperoxides) reduced the antioxidant enzyme levels in plasma and heart tissue of ISO‐directed rats. However, geraniol treatment prevents ISO‐directed enhancement of the heart rate, cardiac and lipid peroxidative genes; reverted the blood pressure, and antioxidant status in ISO‐directed rats. Furthermore, gene expression results revealed that geraniol treatment inhibited the mitogen‐activated protein kinase (MAPK) proteins, inflammatory responder (tumor necrosis factor‐α, interleukin 6, nuclear factor‐κB), and cardiac fibrotic proteins (matrix metalloproteinase‐2[MMP‐2], MMP‐9) in ISO directed rats. Prdx‐1 is an antioxidant response element, and it can regulate all the antioxidant proteins and it scavenges harmful radicals. Therefore, enhanced Prdx‐1 expression is considered to have a pivotal role in preventing cardiac infarction. In this study, an elevated expression of Prdx1 was noticed in geraniol treated with ISO‐directed rats. Hence, we concluded that geraniol is considered a potential phytodrug, and it prevents ISO‐directed MAPKs, inflammation, and cardiac markers by enhancing the expression of Prdx1.