Expanding the view of the molecular mechanisms of autophagy pathway. Issue 8 (5th July 2022)

• Record Type: Journal Article
• Authors: Majeed, Sheikh Tahir; Majeed, Rabiya; Andrabi, Khurshid I.
• Is Part Of: Journal of cellular physiology. Volume 237:Issue 8(2022)
• Page Start: 3257
• Page End: 3277
• Publication Date: 2022-07-05
• Subjects: ATG proteins -- autophagosome -- autophagy -- lysosomes -- phagophore -- ULK1 complex; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30819
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Autophagy is an evolutionarily conserved multistep degradation mechanism in eukaryotes, that maintains cellular homoeostasis by replenishing cells with nutrients through catabolic lysis of the cytoplasmic components. This critically coordinated pathway involves sequential processing events that begin with initiation, nucleation, and elongation of phagophores, followed by the formation of double‐membrane vesicles known as autophagosomes. Finally, autophagosomes migrate towards and fuse with lysosomes in mammals and vacuoles in yeast and plants, for the eventual degradation of the intravesicular cargo. Here, we review the recent advances in our understanding of the molecular events that define the process of autophagy.