Bromodomain AAA+ ATPases get into shape. Issue 1 (1st January 2020)

• Record Type: Journal Article
• Authors: Murawska, Magdalena; Ladurner, Andreas G.
• Is Part Of: Nucleus. Volume 11: Issue 1(2020)
• Page Start: 32
• Page End: 34
• Publication Date: 2020-01-01
• Subjects: Abo1 -- bromodomain AAA+ ATPase -- histone chaperone; Cell nuclei -- Periodicals; Biology -- Periodicals; Biology; Cell nuclei; Periodicals; 571.6605
• DOI: 10.1080/19491034.2020.1741304
• Languages: English
• ISSNs: 1949-1034

Abstract

ABSTRACT: Bromodomain AAA+ ATPases (A TPases a ssociated with diverse cellular a ctivities) are emerging as oncogenic proteins and compelling targets for anticancer therapies. However, structural and biochemical insight into these machines is missing. A recent study by Cho et al . reports the first cryo-EM structure of a bromodomain AAA+ ATPase and provides first insights into the functions of this putative histone chaperone.