The anti-obesity effect of fermented tremella/blueberry and its potential mechanisms in metabolically healthy obese rats. (November 2021)

• Record Type: Journal Article
• Authors: Sheng, Zhili; Yu, Limei; Li, Xue; Zhao, Yang; Dai, Weichang; Chang, Sui Kiat; Liu, Junmei
• Is Part Of: Journal of functional foods. Volume 86(2021)
• Publication Date: 2021-11
• Subjects: Fermented tremella/blueberry -- Metabolically healthy obesity -- Anti-obesity -- Lipid profiles -- Intestinal microbiota -- Short-chain fatty acids; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2021.104670
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: A metabolically healthy obesity (MHO) rat model was established in this study. The anti-obesity potential of fermented Tremella/blueberry (FTB) was evaluated. FTB reduced body weight and improved lipid profiles of MHO rats. FTB modulated the diversity of gut microbiota and metabolites profile. Abstract: Fermented fruits or vegetables has attracted much attention by researchers over the world due to the diverse health benefits and desirable flavor characteristics. In this work, a metabolically healthy obesity (MHO) model was established to investigate the effects of fermented tremella/blueberry (FTB) on the food intake, body weight and blood lipid profiles in MHO rats. The intestinal microbiota and short-chain fatty acids (SCFAs) compositions were also determined. FTB demonstrated significant anti-obesity activity by reducing body weight and improving blood lipid profiles in MHO rats. FTB treatment also modulated the diversity of intestinal microbiota. The bacterial abundance related to obesity prevention ( Allobaculum, Blautia, Parabacteroides and Prevotella ) were increased while the abundances of pathogenic bacteria were reduced. The amounts of specific health promoting SCFAs were also increased. This study was the first to document the anti-obesity potential of FTB in MHO model, indicating its potential as a functional food for obesity prevention.