Concise Review: Organ Engineering: Design, Technology, and Integration. (25th October 2016)

• Record Type: Journal Article
• Authors: Kaushik, Gaurav; Leijten, Jeroen; Khademhosseini, Ali
• Is Part Of: Stem cells. Volume 35:Number 1(2017:Jan.)
• Page Start: 51
• Page End: 60
• Publication Date: 2016-10-25
• Subjects: Organ engineering -- Tissue engineering -- Three-dimensional printing -- Microfluidics -- Developmental biology; Cloning -- Periodicals; Clone cells -- Periodicals; Stem cells -- Periodicals; Cell Differentiation -- Periodicals; Cell Division -- Periodicals; Clone Cells -- Periodicals; Hematopoietic Stem Cells -- Periodicals; Stem Cells -- Periodicals; 571.84
• DOI: 10.1002/stem.2502
• Languages: English
• ISSNs: 1066-5099

Abstract

Abstract : Engineering complex tissues and whole organs has the potential to dramatically impact translational medicine in several avenues. Organ engineering is a discipline that integrates biological knowledge of embryological development, anatomy, physiology, and cellular interactions with enabling technologies including biocompatible biomaterials and biofabrication platforms such as three-dimensional bioprinting. When engineering complex tissues and organs, core design principles must be taken into account, such as the structure-function relationship, biochemical signaling, mechanics, gradients, and spatial constraints. Technological advances in biomaterials, biofabrication, and biomedical imaging allow for in vitro control of these factors to recreate in vivo phenomena. Finally, organ engineering emerges as an integration of biological design and technical rigor. An overall workflow for organ engineering and guiding technology to advance biology as well as a perspective on necessary future iterations in the field is discussed.