Concise Review: Stem Cells in Pancreatic Cancer: From Concept to Translation. (14th August 2015)

• Record Type: Journal Article
• Authors: Raj, Deepak; Aicher, Alexandra; Heeschen, Christopher
• Is Part Of: Stem cells. Volume 33:Number 10(2015:Oct.)
• Page Start: 2893
• Page End: 2902
• Publication Date: 2015-08-14
• Subjects: Pancreatic ductal adenocarcinoma -- Cancer stem cells -- Stromal cells -- Therapeutics/intervention; Cloning -- Periodicals; Clone cells -- Periodicals; Stem cells -- Periodicals; Cell Differentiation -- Periodicals; Cell Division -- Periodicals; Clone Cells -- Periodicals; Hematopoietic Stem Cells -- Periodicals; Stem Cells -- Periodicals; 571.84
• DOI: 10.1002/stem.2114
• Languages: English
• ISSNs: 1066-5099

Abstract

Abstract: Pancreatic cancer stem cells (CSCs) have been first described in 2007 and since then have emerged as an intriguing entity of cancer cells with distinct functional features including self-renewal and exclusive in vivo tumorigenicity. The heterogeneous pancreatic CSC pool has been implicated in tumor propagation as well as metastatic spread. Clinically, the most important feature of CSCs is their strong resistance to standard chemotherapy, which results in fast disease relapse, even with today's more advanced chemotherapeutic regimens. Therefore, novel therapeutic strategies to most efficiently target pancreatic CSCs are being developed and their careful clinical translation should provide new avenues to eradicate this deadly disease. Stem Cells 2015;33:2893—2902