Biobased poly(glycerol citrate) synthesis optimization via design of experiments. (12th September 2021)

• Record Type: Journal Article
• Authors: Gadomska‐Gajadhur, Agnieszka; Bandzerewicz, Aleksandra; Wrzecionek, Michał; Ruśkowski, Paweł
• Other Names: Penczek Stanislaw guestEditor.; Matyjaszewski Krzysztof guestEditor.
• Is Part Of: Polymers for advanced technologies. Volume 32:Number 10(2021)
• Page Start: 3982
• Page End: 3994
• Publication Date: 2021-09-12
• Subjects: citric acid -- DoE -- glycerol -- optimization -- poly(glycerol citrate); Polymers -- Periodicals; 668.9
• DOI: 10.1002/pat.5498
• Languages: English
• ISSNs: 1042-7147

Abstract

Abstract: Nowadays, glycerol polyesters are willingly studied, due to their potential to use in tissue engineering and drug delivery systems. Poly(glycerol citrate) is a quite new material that could have very interesting properties because of the easy formation of three‐dimensional hydrophilic networks. Moreover, both glycerol and citric acid are commonly used chemicals in the food and pharmaceutical industry. They are cheap, well available, and well‐known substances. In this work poly(glycerol citrate) was synthesized in bulk polycondensation with water removal. The polyester structure was widely characterized by FTIR, NMR, GPC, and the end group titration methods. The synthesis procedure was optimized and described via five mathematical models with the use of the design of experiments. The presented method was developed for further industrial use and allows for avoiding gelling phenomena. Based on this work, poly(glycerol citrate) could be obtained with desired properties, moreover, the process is prepared for scaling‐up.