Construction of a Single‐Atom Nanozyme for Enhanced Chemodynamic Therapy and Chemotherapy. Issue 53 (4th August 2021)

• Record Type: Journal Article
• Authors: Liu, Yong; Yao, Mei; Han, Wenxiu; Zhang, Huairong; Zhang, Shusheng
• Is Part Of: Chemistry. Volume 27:Issue 53(2021)
• Page Start: 13418
• Page End: 13425
• Publication Date: 2021-08-04
• Subjects: cancer cell membrane -- chemodynamic therapy -- chemotherapy -- single-atom catalysts; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202102016
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: To fulfill the demand of precision and personalized medicine, single‐atom catalysts (SACs) have emerged as a frontier in biomedical fields due to enzyme‐mimic catalysis. Herein, we present a biocompatible and versatile nanoagent consisting of single‐atom iron‐containing nanoparticles (SAF NPs), DOX and A549 cell membrane (CM). The designed porous iron‐based SACs originally served as a drug‐carrying nanoplatform to release DOX selectively in a tumor microenvironment (TME) for chemotherapy (CT) due to their high loading capacity (155 %) for DOX; this signifies that SACs are promising candidates for universal cargo delivery. Besides, the designed single‐atom nanoagent can perform like peroxidase, which effectively triggers an in situ tumor‐specific Fenton reaction to generate abundant toxic hydroxyl radicals (⋅OH) selectively in the acidic TME for chemodynamic therapy (CDT). With the combination of CDT and CT, the constructed SAF NPs@DOX@CM nanoagent demonstrates better in vivo therapeutic performance than single‐pathway therapy. In the meantime, after modification with CM, SAF NPs@DOX@CM can achieve homologous binding to target tumor tissues and avoid early clearance. This study presents a type of multifunctional SACs for enhanced cancer treatment via the capacity of a drug carrier combined with the enzymatic therapies of single‐atom catalytic sites. Abstract : Only where it's wanted : Iron‐based single‐atom nanozymes (SAF NPs) that can effectively generate abundant ⋅OH selectively in the tumor microenvironment for chemodynamic therapy, were modified with cell membrane and employed as an effective drug‐carrying nanoplatform for the first time. SAF NPs exhibit superior catalytic property and high loading capacity (155 %) for DOX; this makes it possible to combine the enzymatic therapies of SACs and tumor chemotherapy.