Clinical efficacy of different therapeutic modes of CO2 fractional laser for treatment of static periocular wrinkles in Asian skin. (8th December 2021)

• Record Type: Journal Article
• Authors: Gao, Lin; Song, Wenting; Qian, Linhan; Zhang, Jine; Li, Kai; Yang, Juan; Wang, Gang
• Is Part Of: Journal of cosmetic dermatology. Volume 21:Number 3(2022)
• Page Start: 1045
• Page End: 1050
• Publication Date: 2021-12-08
• Subjects: fractional laser -- periorbital wrinkles -- skin aging; Skin -- Diseases -- Treatment -- Periodicals; Lasers in surgery -- Periodicals; Skin -- Pathophysiology -- Periodicals; Surgery, Plastic -- Periodicals; 616.5
• DOI: 10.1111/jocd.14640
• Languages: English
• ISSNs: 1473-2130

Abstract

Abstract: Background: Periocular fine lines and wrinkles usually appear as a first visible sign of facial aging. Fractional ablative laser has been used to treat periorbital wrinkles. Objective: To compare the efficacy on treatment of static periorbital wrinkles using different emission modes of CO2 fractional laser. Methods: A total of 30 patients with static periorbital wrinkles were enrolled. The subjects were randomly assigned into two split‐face groups: One side was treated with a deep ( n = 15) or mid‐mode of CO2 superficial laser ( n = 15), and the other side of periocular region was treated by a fusion mode in combination of both modes ( n = 30). Results: The patients in three groups showed significant improvements on indexes of periocular wrinkles, skin textures, and elasticity at three‐month follow‐up as compared with baseline ( p < 0.05). Fusion mode resulted in a significantly progressive improvement on periocular wrinkles at three‐month follow‐up as compared with one‐month follow‐up ( p < 0.05), which were not observed in other modes. Fusion mode delivered better improvements of periocular wrinkles and skin textures as compared to deep and mid‐modes at three‐month follow‐up ( p < 0.05). Fusion mode also resulted in better scores of global esthetic improvement scale and patient satisfaction as compared to other modes at both follow‐ups. Conclusion: The fusion mode has a synergistic effect in periorbital static wrinkle treatment, which is worthy of further evaluation and investigation.