Poor postnatal weight growth is a late finding after sepsis in very preterm infants. Issue 3 (4th November 2020)

• Record Type: Journal Article
• Authors: Flannery, Dustin D; Jensen, Erik A; Tomlinson, Lauren A; Yu, Yinxi; Ying, Gui-Shuang; Binenbaum, Gil
• Other Names: author non-byline.; Binenbaum Gil author non-byline.; Tomlinson Lauren A. author non-byline.; Duros Trang B. author non-byline.; Nguyen Anh author non-byline.; Ying Gui-shuang author non-byline.; Maguire Maureen G. author non-byline.; Brightwell-Arnold Mary author non-byline.; Shaffer James author non-byline.; Yu Yinxi author non-byline.; Blanco Maria author non-byline.; Brown Trina author non-byline.; Helker Christopher P. author non-byline.; Hutchinson Amy author non-byline.; Young Carrie author non-byline.; McCourt Emily author non-byline.; Lynch Anne author non-byline.; Cathcart Jennifer author non-byline.; Cerda Ashlee author non-byline.; Bonnell Levi author non-byline.; Thevarajah Tamara author non-byline.; Barry Gerard P. author non-byline.; Fisher Marilyn author non-byline.; Battaglia Maria V author non-byline.; Drach Alex M author non-byline.; Hughes Kevin author non-byline.; Chinnakaruppan Nachammai author non-byline.; Meyer Andrew author non-byline.; Gogal Christina author non-byline.; Beitler Cynthia author non-byline.; Centolanza Lauri author non-byline.; Moyer Keith T. author non-byline.; Sobotor Mary author non-byline.; Donohue Pamela author non-byline.; Repka Michael X author non-byline.; Shepard Jennifer A author non-byline.; Doherty Megan author non-byline.; Reynolds James D. author non-byline.; Connelly Erin author non-byline.; Cheeseman Edward author non-byline.; Shirer Kinsey author non-byline.; Bradham Carol author non-byline.; McAlpine Allison author non-byline.; Sunthankar Sudeep author non-byline.; Abbasian Javaneh author non-byline.; Lim Janet author non-byline.; Yang Michael author non-byline.; Cobb Patricia author non-byline.; Alfano Elizabeth L author non-byline.; Rogers David author non-byline.; Reem Rachel E author non-byline.; Schreckengost Amanda author non-byline.; Fellows Rae R author non-byline.; Loh Kaitlyn author non-byline.; McGregor Madeline A author non-byline.; Mustafa Thabit author non-byline.; Dean Ivy author non-byline.; Miller Rachel author non-byline.; Russell Tess author non-byline.; Stattler Rebecca author non-byline.; Maletic Sara author non-byline.; Selph Theran Jake author non-byline.; Young David author non-byline.; Siu Andrea author non-byline.; Kanemori Michele author non-byline.; Kingston George author non-byline.; Geloneck Megan author non-byline.; Feldman Robert author non-byline.; Baker Ted author non-byline.; Baker Laura author non-byline.; Melese Ephrem author non-byline.; Haider Kathryn author non-byline.; Wang Jingyun author non-byline.; Hynes Elizabeth author non-byline.; Bell Edward F author non-byline.; Dumitrescu Alina V. author non-byline.; Klein Jonathan M. author non-byline.; Cress Gretchen A. author non-byline.; Ajjarapu Avanthi S. author non-byline.; Berge Kristine author non-byline.; Boeshart Eric author non-byline.; Dorsey Morgan author non-byline.; Funk Bethany M. author non-byline.; Hach Grace author non-byline.; Johnson Claire L. author non-byline.; Kurian Kevin author non-byline.; Miller Emily author non-byline.; Platt Angela C. author non-byline.; Law Christine author non-byline.; Gissing Andrew author non-byline.; Khazaeni Leila author non-byline.; Dunbar Jennifer author non-byline.; Hawkins Kelley author non-byline.; Lee Sharon author non-byline.; Sung Lily author non-byline.; Leggitt Carly author non-byline.; Ramasubramanian Aparna author non-byline.; Bhola Rahul author non-byline.; Bottorff Michelle author non-byline.; Dimova Neviana author non-byline.; Keith Rachel author non-byline.; Thomas Laura author non-byline.; Anderson Jill author non-byline.; Areaux Raymond G. author non-byline.; Holleschau Ann Marie author non-byline.; Gross Jordan author non-byline.; Kramer Andrea author non-byline.; Morrison David author non-byline.; Donahue Sean author non-byline.; Wilkins Carsyn Saige author non-byline.; Fukuda Neva author non-byline.; Owings Sandy author non-byline.; Ruark Scott author non-byline.; Michael Siatkowski R author non-byline.; Bhatti Faizah author non-byline.; Bergman Vanessa author non-byline.; Corff Karen author non-byline.; Harkey Kari author non-byline.; Manfredo Amy author non-byline.; Helmbrecht Ashley author non-byline.; Talsania Shrenik author non-byline.; Whisenhunt Terri author non-byline.; Suh Donny author non-byline.; Berry Ann Anderson author non-byline.; Lynes Denise author non-byline.; Erikson Kelly C. author non-byline.; Binenbaum Gil author non-byline.; Abbasi Soraya author non-byline.; Kirpalani Haresh author non-byline.; Quinn Graham E. author non-byline.; Dawson Lindsay author non-byline.; Tomlinson Lauren A author non-byline.; Sylvester Christin author non-byline.; Nischal Kanwal author non-byline.; Runkel Lauren author non-byline.; Chen Wendy S. author non-byline.; Jackson Deidrya author non-byline.; Davitt Bradley author non-byline.; Govreau Dawn author non-byline.; Breuer Linda author non-byline.; Noonan September author non-byline.; Hoffman Robert author non-byline.; Beachy Joanna author non-byline.; Farnsworth Kelliann author non-byline.; Farnsworth Katie Jo author non-byline.; Harrison Deborah author non-byline.; Bernhisel Ashlie author non-byline.; Carlstrom Bonnie author non-byline.;
• Is Part Of: Archives of disease in childhood. Volume 106:Issue 3(2021)
• Page Start: 298
• Page End: 304
• Publication Date: 2020-11-04
• Subjects: neonatology -- growth -- microbiology; Infants -- Diseases -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.920105
• DOI: 10.1136/archdischild-2020-320221
• Languages: English
• ISSNs: 1359-2998

Abstract

Abstract : Objective: To characterise the association between sepsis and postnatal weight growth when accounting for the degree of growth restriction present at birth. Design: Retrospective matched cohort study using data from the Postnatal Growth and Retinopathy of Prematurity study. Participants were born with birth weights of <1500 g or gestational ages of <32 weeks between 2006 and 2011 at 29 neonatal centres in the USA and Canada. Sepsis was defined as a culture-confirmed bacterial or fungal infection of the blood or cerebrospinal fluid before 36 weeks' postmenstrual age (PMA). Growth was assessed as the change in weight z-score between birth and 36 weeks' PMA. Results: Of 4785 eligible infants, 813 (17%) developed sepsis and 693 (85%) were matched 1:1 to controls. Sepsis was associated with a greater decline in weight z-score (mean difference −0.09, 95% CI −0.14 to −0.03). Postnatal weight growth failure (decline in weight z- score>1) was present in 237 (34%) infants with sepsis and 179 (26%) controls (adjusted OR 1.49, 95% CI 1.12 to 1.97). Longitudinal growth trajectories showed similar initial changes in weight z-scores between infants with and without sepsis. By 3 weeks after sepsis onset, there was a greater decline in weight z-scores relative to birth values in those with sepsis than without sepsis (delta z-score −0.89 vs −0.77; mean difference −0.12, 95% CI −0.18 to −0.05). This significant difference persisted until 36 weeks or discharge. Conclusion: Infants with sepsis had similar early weight growth trajectories as infants without sepsis but developed significant deficits in weight that were not apparent until several weeks after the onset of sepsis.