2, 3‐Pentandion – Bestimmung von 2, 3‐Pentandion in der Luft am Arbeitsplatz mittels Hochleistungsflüssigchromatographie (HPLC) [Air Monitoring Methods in German language, 2017]. Issue 4 (27th October 2017)

• Record Type: Journal Article
• Authors: Schuh, C.; Nitschke, L.; Hebisch, R.; Hartwig, A.
• Is Part Of: MAK collection for occupational health and safety. Volume 2:Issue 4(2017)
• Page Start: 1644
• Page End: 1658
• Publication Date: 2017-10-27
• Subjects: 2, 3‐Pentandion -- Arbeitsplatzmessung -- Gefahrstoffe -- Luftanalysen -- Messverfahren -- Hochleistungsflüssigchromatographie -- HPLC‐UV -- HPLC‐MS -- Kurzzeitmessung -- 2, 4‐Dinitrophenylhydrazin; Biological monitoring -- Periodicals; Industrial toxicology -- Periodicals; Hazardous substances -- Periodicals; 615.902
• DOI: 10.1002/3527600418.am60014d0019a
• Languages: English
• ISSNs: 2509-2383

Abstract

Abstract: This analytical method is a validated measurement procedure for the determination of 2, 3‐pentanedione in workplace air in a concentration range of a tenth up to twice the currently valid MAK value of 0.083 mg/m 3 . Sampling is performed by drawing a defined volume of air through a cartridge filled with silica gel impregnated with 2, 4‐dinitrophenylhydrazine (DNPH) using a suitable flow‐regulated pump with a volumetric flow rate of 1 L/min. For sampling 1 hour or 15 min (checking the short‐term value) can be used. The formed derivative 2, 3‐pentanedione bis(2, 4‐dinitrophenylhydrazone) is extracted with desorption agent and analysed by means of high performance liquid chromatography using an UV or a MS detector. The quantitative determination is based on a calibration function obtained by means of a multiple‐point calibration. The absolute limit of quantification (LOQ) is 0.043 ng and the relative LOQ is 0.00078 mg/m 3 based on an air sample volume of approx. 60 L or 0.0031 mg/m 3 based on an air sample volume of approx. 15 L (for short‐term value).