Connection between PD-L1 expression and standardized uptake value in NSCLC: an early prognostic treatment combination. (4th May 2021)

• Record Type: Journal Article
• Authors: Zarogoulidis, Paul; Christakidis, Vagelis; Petridis, Dimitris; Sapalidis, Konstantinos; Kosmidis, Chriforos; Vagionas, Anastasios; Perdikouri, Eleni-Isidora; Hohenforst-Schmidt, Wolfgang; Huang, Haidong; Petanidis, Savvas; Tsakiridis, Kosmas; Baka, Sofia; Romanidis, Konstantinos; Zaric, Bojan; Kovacevic, Tomi; Stojsic, Vladimir; Sarcev, Tatjana; Bursac, Daliborka; Kukic, Biljana; Boukovinas, Ioannis; Tolis, Christos; Sardeli, Chrysanthi
• Is Part Of: Expert review of respiratory medicine. Volume 15:Number 5(2021)
• Page Start: 675
• Page End: 679
• Publication Date: 2021-05-04
• Subjects: PET-CT -- lung cancer -- bronchoscopy -- EBUS-TBNA -- SUV; Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Diseases -- Treatment -- Periodicals; 616.2005
• DOI: 10.1080/17476348.2021.1859373
• Languages: English
• ISSNs: 1747-6348

Abstract

ABSTRACT: Objectives : Lung cancer is still diagnosed at advanced stage and early treatment initiation is needed. Therefore, we need biomarkers or clusters of information that can provide early treatment prognosis. Methods : Biopsies were acquired from 471 patients-lung masses with CT-guided biopsy, convex probe transthorasic biopsy, and EBUS-TBNA convex probe with 18 G needles and 19 G needles. Results : Standardized uptake value (SUV) measurement is associated with female, smoking status, hepatic metastasis, adenocarcinoma and programmed death-ligand 1 (PD-L1). In specific we expect that SUV ≥ 7 is associated with PD-L1 ≥ 50. Conclusions : Lung masses indifferent of size that have SUV ≥ 7 will also have PD-L1 expression ≥ 50. Also, it is likely that these patients will be female with intense smoking habit and hepar or multiple metastasis.