Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation. Issue 1 (2nd January 2021)

• Record Type: Journal Article
• Authors: Voorhees, Timothy J.; Kannan, Kavya K.; Galeotti, Jonathan; Grover, Natalie; Vaidya, Rakhee; Moore, Dominic T.; Montgomery, Nathan D.; Beaven, Anne W.; Dittus, Christopher
• Is Part Of: Leukemia & lymphoma. Volume 62:Issue 1(2021)
• Page Start: 86
• Page End: 94
• Publication Date: 2021-01-02
• Subjects: Post-transplant lymphoproliferative disorder -- PTLD -- monomorphic -- outcome -- survival; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2020.1821006
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Monomorphic post-transplant lymphoproliferative disorder (M-PTLD) occurring after solid organ transplant histologically resembles aggressive non-Hodgkin lymphomas, with diffuse large B-cell lymphoma being the most common. In a cohort of 40 patients with DLBCL-type M-PTLD, inferior progression free survival (PFS) was observed for Revised International Prognostic Index (R-IPI) >2 ( p = 0.01) and high-risk pathologic features ( p = 0.02), defined by double expressor lymphoma, MYC rearrangement, or increased copy number of either MYC or BCL2 . Overall survival (OS) was inferior in R-IPI >2 ( p = 0.002) and high-risk pathologic features ( p = 0.003). Combining both R-IPI >2 and high-risk pathologic features resulted in well-delineated good, intermediate, and poor risk groups of DLBCL-type M-PTLD with respect to both PFS and OS ( p < 0.001). Our results demonstrate a prognostic role for both the R-IPI score and presence of high-risk pathologic features in DLBCL-type M-PTLD.