Biophysical optimization of preimplantation embryo culture: what mechanics can offer ART. (8th January 2021)

• Record Type: Journal Article
• Authors: Hawkins, Jamar; Miao, Xiaosu; Cui, Wei; Sun, Yubing
• Is Part Of: Molecular human reproduction. Volume 27:Number 1(2021)
• Publication Date: 2021-01-08
• Subjects: preimplantation -- embryo -- zona pellucida -- mechanobiology -- shear stress -- substrate stiffness -- microfluidics -- biophysics -- IVF -- hatching; Human reproduction -- Molecular aspects -- Periodicals; Electronic journals; 612.6
• DOI: 10.1093/molehr/gaaa087
• Languages: English
• ISSNs: 1360-9947

Abstract

Abstract: Owing to the rise of ART and mounting reports of epigenetic modification associated with them, an understanding of optimal embryo culture conditions and reliable indicators of embryo quality are highly sought after. There is a growing body of evidence that mechanical biomarkers can rival embryo morphology as an early indicator of developmental potential and that biomimetic mechanical cues can promote healthy development in preimplantation embryos. This review will summarize studies that investigate the role of mechanics as both indicators and promoters of mammalian preimplantation embryo development and evaluate their potential for improving future embryo culture systems.