Phosphine‐Free Manganese(II)‐Catalyst Enables Acceptorless Dehydrogenative Coupling of Alcohols with Indoles. Issue 18 (29th July 2021)

• Record Type: Journal Article
• Authors: Yadav, Vinita; Balaraman, Ekambaram; Mhaske, Santosh B.
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 18(2021)
• Page Start: 4430
• Page End: 4439
• Publication Date: 2021-07-29
• Subjects: manganese -- phosphine-free -- acceptorless dehydrogenation -- alcohol -- indole; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202100621
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Herein, an air‐stable, molecularly defined NNN−Mn(II) pincer complex catalyzed acceptorless dehydrogenative coupling of alcohols with indoles is reported. A wide variety of symmetrical and unsymmetrical bis(indolyl)methane derivatives as well as some structurally important products such as Vibrindole A, Turbomycin B alkaloid, Antileukemic, and Anticancer agents were synthesized. Mechanistic studies illustrate the importance of the NH moiety in the complex and the crucial role of metal‐ligand cooperation during catalysis. Abstract :