Styryl pyranones with apoptosis activities from the sporocarps of Phellinus igniarius. (August 2021)

• Record Type: Journal Article
• Authors: Cao, Yinglong; Liu, Yi; Wang, Ge; Wang, Wenqiong; Li, Yougui; Xuan, Lijiang
• Is Part Of: Phytochemistry letters. Volume 44(2021)
• Page Start: 154
• Page End: 159
• Publication Date: 2021-08
• Subjects: Phellinus igniarius -- Styryl pyranones -- Cell apoptosis; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2021.06.018
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Chemical constituents of the sporocarps of Phellinus igniarius were isolated and identified. Three novel styryl pyranones were reported in this paper. Compound 4 and 10 can increase Hela-/- cell death via activating apoptosis pathway other than necroptosis. Abstract: Three previously unreported compounds, phelliigniarin A (1 ), phelliigniarin B (2 ), phelliigniarin C (3 ), and seven known compounds were isolated and identified from the sporocarps of Phellinus igniarius . These structures were elucidated on the basis of spectroscopic analysis. Compound 4 and 10 triggered apoptosis of Hela-/- cell at the dose of 20 μM.