Circulating microbiome DNA: An emerging paradigm for cancer liquid biopsy. (28th November 2021)

• Record Type: Journal Article
• Authors: Chen, Haiming; Ma, Yi; Liu, Zheng; Li, Jiawei; Li, Xiao; Yang, Fan; Qiu, Mantang
• Is Part Of: Cancer letters. Volume 521(2021)
• Page Start: 82
• Page End: 87
• Publication Date: 2021-11-28
• Subjects: Circulating microbiome DNA -- Bacteria -- Carcinogenesis -- Diagnostic biomarkers; cmDNA circulating microbiome DNA -- F.N Fusobacterium nucleatum -- MDSCs myeloid-derived suppressor cells -- TANs tumor-associated neutrophils -- H.P Helicobacter pylori -- Cag-A Cytotoxin-associated gene A -- ETBF enterotoxigenic Bacteroides fragilis -- ctDNA circulating tumor DNA -- CO2 carbon dioxide -- NH3 ammonia; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2021.08.036
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Dysbiosis of the human microbiome has long been reported to be closely associated with various cancers. Accumulating studies have shown that microbial dysbiosis can accelerate tumorigenesis through tumor-promoting inflammation, DNA damage, and inducing immune evasion. Differential composition of microbiome could be novel biomarkers for cancer detection or biomarkers of successful immunotherapy. More importantly, emerging evidence demonstrates that alterations of circulating microbiome DNA (cmDNA) could serve as promising noninvasive biomarkers for cancer detection. It has been reported that distinct circulating bacterial DNA could distinguish prostate cancer, lung cancer, and melanoma patients from healthy populations. Therefore, in this review, we summarized current literature on microbial biomarkers for cancer detection and unraveled the potential of cmDNA as a promising cancer detection tool. Highlights: Microbial dysbiosis could promote carcinogenesis of various cancers. Microbiota exists in both tumor tissues and blood of cancer patients. Circulating microbiome DNA is an emerging paradigm for liquid biopsy.