Assessment on chronic and transgenerational toxicity of methamphetamine to Caenorhabditis elegans and associated aquatic risk through toxicity indicator sensitivity distribution (TISD) analysis. (1st November 2021)

• Record Type: Journal Article
• Authors: Wang, Zhenglu; Dai, Shuiping; Wang, Jinze; Du, Wei; Zhu, Lin
• Is Part Of: Environmental pollution. Volume 288(2021)
• Publication Date: 2021-11-01
• Subjects: Methamphetamine -- Underlying molecular mechanism -- Toxicity indicator sensitivity distribution -- Risk assessment; TISD toxicity indicator sensitivity distribution -- METH methamphetamine -- SSD species sensitivity distribution -- RQ risk quotient -- EC emerging contaminants -- PPCPs pharmaceuticals and personal care products -- CPP conditioned place preference -- C. elegans Caenorhabditis elegans -- ECOSAR US EPA Ecological Structure Activity Relationships -- TGD technical guidance document -- HC5 hazardous concentration for 5% of species -- SSDs species sensitivity distributions -- EC10 10% effective concentration -- C10 90% protection concentration -- PNEC predicted no effects concentration -- NGM nematode growth medium -- ROS reactive oxygen species -- H2DCFDA 2', 7'-dichlorodihydrofluoresceindiacetate acetyl ester -- PCR polymerase chain reaction -- CF concentration affecting F% of the indicators -- MEC measured environmental concentration -- PNEC predicted no effect concentration -- AF assessment factor -- PCA principal component analysis -- LOEC lowest observed effect concentration -- CN China -- AU Australia -- EU Europe -- US United States -- LC50 lethal concentration of 50%; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2021.117696
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Evidence about the adverse effects of methamphetamine (METH) on invertebrates is scarce. Hence, C. elegans, a representative invertebrate model, was exposed to METH at environmental levels to estimate chronic and transgenerational toxicity. The results of chronic exposure were integrated into an underlying toxicity framework of METH in invertebrates (e.g., benthos) at environmentally relevant concentrations. The induction of cellular oxidative damage-induced apoptosis and fluctuation of ecologically important traits (i.e., feeding and locomotion) might be attributed by the activation of the longevity regulating pathway regulated by DAF-16/FOXO, and detoxification by CYP family enzymes. The adverse effects to the organism level included impaired viability and decreased fecundity. The results from transgenerational exposure elucidated the cumulative METH-induced damage in invertebrates. Finally, a new risk assessment method named toxicity indicator sensitivity distribution (TISD) analysis was proposed by combining multiple toxicity indicator test data (ECx ) to derive the hazardous concentration for 10% indicators (C10 ) of one species. The risk quotient (RQ) values calculated by measured environmental concentrations and C10 in southern China, southeastern Australia, and the western US crossed the alarm line (RQ = 5), suggesting a need for long-term monitoring. Graphical abstract: Image 1 Highlights: Low dose methamphetamine induced cumulative damage on generations of C. elegans . Underlying toxicity mechanisms of methamphetamine to invertebrates were elucidated. Toxicity indicator sensitivity distribution was confirmed as new risk assessment tool. The risk levels in south China, south Australia, and west US crossed alarm line.