Flexible Osteogenic Glue as an All‐In‐One Solution to Assist Fracture Fixation and Healing. (2nd July 2021)

• Record Type: Journal Article
• Authors: Tang, Jincheng; Xi, Kun; Chen, Hao; Wang, Lingjun; Li, Dongya; Xu, Yun; Xin, Tianwen; Wu, Liang; Zhou, Yidi; Bian, Jiang; Cai, Zhengwei; Yang, Huilin; Deng, Lianfu; Gu, Yong; Cui, Wenguo; Chen, Liang
• Is Part Of: Advanced functional materials. Volume 31:Number 38(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-07-02
• Subjects: comminuted fractures -- flexible fixation -- orthopedic adhesive -- osteogenesis; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202102465
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Osteogenic glue that reproduces the natural bone composition represents the final frontier of orthopedic adhesives with the potential to revolutionize surgical strategies against comminuted fractures. However, it is difficult to achieve an all‐in‐one formula, which could provide flexible and reliable adhesiveness while avoiding interfering with or even promoting the healing of glued fractures. Herein, an osteogenic glue characterized by inorganic‐in‐organic integration between amine‐modified mesoporous bioactive glass nanoparticles (AMBGN) and bioadhesive gelatin‐dextran network (GelDex) is introduced as an all‐in‐one tool to flexibly adhere and splice bone fragments and subsequently guide fracture healing during degradation. Relying on such integration, a 4‐fold improvement in cohesiveness is presented, followed by a nearly 5‐fold enhancement in adhesive strength in ex vivo porcine bone samples. The reversible and re‐adjustable adhesiveness also enables glue to effectively splice intricate fragments from highly comminuted fractures in the rabbit radius in an in vivo environment. Moreover, well‐preserved organic–inorganic integrity during degradation of the glue guides sustained interfacial osteogenesis and achieve satisfying healing outcomes in glued fractures, as observed by the 2‐fold improvement in biomechanical and radiological performance compared with commercially available cyanoacrylate adhesives. The current findings propose an all‐in‐one solution for the fixation of bone fragments during surgery. Abstract : An osteogenic glue capable of flexibly adhering and splicing bone fragments and guiding the subsequent fracture healing process during degradation is constructed via inorganic‐in‐organic integration between a bioadhesive GelDex network and amine‐modified mesoporous bioactive glass nanoparticles so as to provide an all‐in‐one tool assisting fixation and healing of bone fragments in comminuted fractures.