The interaction of aging with serum 25(OH)D and 1, 25(OH)2 D status on muscle strength. Issue 10 (25th June 2021)

• Record Type: Journal Article
• Authors: Davarzani, Samira; Djafarian, Kurosh; Clark, Cain C. T.; Babaei, Nadia; Ghorbaninejad, Parivash; Ebaditabar, Mojdeh; Shab‐Bidar, Sakineh
• Is Part Of: International journal of clinical practice. Volume 75:Issue 10(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-06-25
• Subjects: Clinical medicine -- Periodicals; Medicine -- Periodicals; 610.5
• DOI: 10.1111/ijcp.14510
• Languages: English
• ISSNs: 1368-5031

Abstract

Abstract: Background: To investigate the combination relationship of age with serum 25‐hydroxyvitamin D (25(OH) D) and 1, 25‐(OH)2D3 levels on muscle strength. Methods: We performed a cross‐sectional study on 270 subjects containing 115 men and 155 women. Serum concentration of 25(OH) D and 1, 25‐(OH)2D3 were assessed. Hand grip strength (HGS) was measured using a digital dynamometer. Results: There was no significant difference in mean of HGS among tertiles of 25(OH)D ( P = .350) and 1, 25(OH)2 D ( P = .467) before and after controlling for potential confounding factors. A significant difference in HGS was found between age categories in both crude ( P < .001) and adjusted models ( P = .018), where mean grip strength increased in the three first age categories, but decreased in the last group (48‐69 years old). There was also a significant interaction between age and 25(OH) D ( P = .049) and 1, 25‐(OH)2D3 ( P = .047) on HGS, in which the combination effect increased the mean of muscle strength up to middle age after adjusting for confounders. Conclusions: Serum 25(OH)D and 1, 25(OH)2 D were not related to muscle strength. However, age, and combination of age with both 25(OH)D and 1, 25(OH)2 D, significantly resulted in improving in muscle strength up to middle age.