Organocatalytic Enantioselective Construction of Acyclic N, N‐Acetals via Aza‐Addition of Arylamines to Ketimines. Issue 18 (29th July 2021)

• Record Type: Journal Article
• Authors: Lin, Xiao; Ge, Keli; He, Ningning; Chen, Xuling; Li, Pengfei; Dong, Mingxin; Li, Wenjun
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 18(2021)
• Page Start: 4332
• Page End: 4337
• Publication Date: 2021-07-29
• Subjects: N, N-Acetal -- Arylamine -- Enantioselectivity -- Ketimine -- Organocatalysis; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202100600
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A chiral phosphoric acid catalyzed enantioselective aza‐addition of arylamines to ketimines has been developed for the construction of chiral acyclic N, N ‐acetal motifs. Under the standard conditions, arylamines reacted smoothly with ketimines from isoquinoline‐1, 3‐dione to afford a series of acyclic N, N ‐acetals in 82–99% yield with 80–96% ee. Abstract :