A randomised crossover trial of closed loop automated oxygen control in preterm, ventilated infants. (6th October 2020)

• Record Type: Journal Article
• Authors: Sturrock, Sarah; Ambulkar, Hemant; Williams, Emma E.; Sweeney, Samantha; Bednarczuk, Nadja F.; Dassios, Theodore; Greenough, Anne
• Is Part Of: Acta pædiatrica. Volume 110:Number 3(2021)
• Page Start: 833
• Page End: 837
• Publication Date: 2020-10-06
• Subjects: closed loop automated oxygen delivery -- desaturation -- hyperoxia; Pediatrics -- Periodicals; Pediatrics; 618.92
• DOI: 10.1111/apa.15585
• Languages: English
• ISSNs: 0803-5253

Abstract

Abstract: Aim: To determine whether closed loop automated oxygen control resulted in a reduction in the duration and severity of desaturation episodes and the number of blood gases and chest radiographs in preterm, ventilated infants. Methods: Infants were studied on two consecutive days for 12 hours on each day. They were randomised to receive standard care (standard period) or standard care with a closed loop automated oxygen control system (automated oxygen control period) first. Results: Twenty‐four infants with a median gestational age of 25.7 (range 23.1‐32.6) weeks were studied at a median postconceptional age of 27.4 (range 24.3‐34.9) weeks. During the automated oxygen control period, there were fewer desaturations that lasted >30 seconds ( P = .032) or >60 seconds ( P = .002), infants spent a higher proportion of the time within their target SpO2 range during the automated oxygen control period ( P < .001), and fewer manual adjustments were made to the inspired oxygen concentration (mean 0.58 vs mean 11.29) ( P < .001). There were no significant differences in the number of blood gases ( P = .872) or chest radiographs ( P = .366) between the two periods. Conclusion: Closed loop automated oxygen delivery resulted in fewer prolonged desaturations with more time spent in the targeted oxygen range.