COVID‐19 pandemic and mental distress in multiple sclerosis: Implications for clinical management. (3rd November 2020)

• Record Type: Journal Article
• Authors: Costabile, Teresa; Carotenuto, Antonio; Lavorgna, Luigi; Borriello, Giovanna; Moiola, Lucia; Inglese, Matilde; Petruzzo, Martina; Trojsi, Francesca; Ianniello, Antonio; Nozzolillo, Agostino; Cellerino, Maria; Boffa, Giacomo; Rosa, Laura; Servillo, Giuseppe; Moccia, Marcello; Bonavita, Simona; Filippi, Massimo; Lanzillo, Roberta; Brescia Morra, Vincenzo; Petracca, Maria
• Other Names: Moro Elena guestEditor.; Taba Pille guestEditor.
• Is Part Of: European journal of neurology. Volume 28:Number 10(2021)
• Page Start: 3375
• Page End: 3383
• Publication Date: 2020-11-03
• Subjects: coping -- COVID‐19 -- depression -- exercise -- multiple sclerosis; Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.14580
• Languages: English
• ISSNs: 1351-5101

Abstract

Abstract: Background and Purpose: In multiple sclerosis (MS), disease‐related factors and dysfunctional coping might favor the development of mental distress induced by COVID‐19 containment measures. Aim of this study was exploring the relationship between disability, coping strategies, daily life reorganization and neuropsychiatric symptoms in an Italian MS population during the COVID‐19 lockdown, in order to identify potentially modifiable factors that could inform clinical management of mental distress in people with MS. Methods: We explored the relationship between mental distress, disability and coping strategies in the Italian MS population under lockdown. Structural equation modeling was applied to information collected via web survey to identify modifiable factors that could account for mental distress. Results: A total of 845 participants (497 with MS and 348 controls) were included in the study. The MS group had higher scores than the control group for depression ( p = 0.005), but not for anxiety, emotional dyscontrol or sleep disturbances. The structural equation modeling explained 74% of the variance observed in depression score. Within the model, three latent factors were characterized from measured variables: motor disability and cognitive dysfunction contributed to disability (β = 0.509 and β = 0.836; p < 0.001); positive attitude and exercise contributed to active attitude (β = 0.386 and β = 0.297; p < 0.001); and avoidance, social support and watching television contributed to passive attitude (β = 0.301, β = 0.243 and β = 0.212; p < 0.001). With regard to the relationship between latent factors and their influence on depression, disability contributed to passive attitude (β = 0.855; p < 0.001), while both passive and active attitude significantly influenced depression (β = 0.729 and β = −0.456; p < 0.001). Conclusion: As a practical implication of our model, favoring exercise would enhance active attitude and its positive impact on mental well‐being while, at the same time, reducing the negative impact of disability on depression, representing a valuable tool in facing COVID‐19‐related mental distress. Abstract : We used structural equation modeling to explore the relationship between mental distress, disability and coping strategies in the Italian population with multiple sclerosis (MS) under lockdown. A total of 845 people (497 with MS and 348 controls) participated in our web survey; in this population, the MS group had higher scores than the control group for depression ( p = 0.005). According to the structural equation modeling, which explained 74% of the variance observed in depression scores, favoring exercise would enhance active attitude and its positive impact on mental well‐being while, at the same time, reducing the negative impact of disability on depression, representing a valuable tool in facing COVID‐19‐related mental distress.