The ENIGMA‐Epilepsy working group: Mapping disease from large data sets. Issue 1 (29th May 2020)

• Record Type: Journal Article
• Authors: Sisodiya, Sanjay M.; Whelan, Christopher D.; Hatton, Sean N.; Huynh, Khoa; Altmann, Andre; Ryten, Mina; Vezzani, Annamaria; Caligiuri, Maria Eugenia; Labate, Angelo; Gambardella, Antonio; Ives‐Deliperi, Victoria; Meletti, Stefano; Munsell, Brent C.; Bonilha, Leonardo; Tondelli, Manuela; Rebsamen, Michael; Rummel, Christian; Vaudano, Anna Elisabetta; Wiest, Roland; Balachandra, Akshara R.; Bargalló, Núria; Bartolini, Emanuele; Bernasconi, Andrea; Bernasconi, Neda; Bernhardt, Boris; Caldairou, Benoit; Carr, Sarah J.A.; Cavalleri, Gianpiero L.; Cendes, Fernando; Concha, Luis; Desmond, Patricia M.; Domin, Martin; Duncan, John S.; Focke, Niels K.; Guerrini, Renzo; Hamandi, Khalid; Jackson, Graeme D.; Jahanshad, Neda; Kälviäinen, Reetta; Keller, Simon S.; Kochunov, Peter; Kowalczyk, Magdalena A.; Kreilkamp, Barbara A.K.; Kwan, Patrick; Lariviere, Sara; Lenge, Matteo; Lopez, Seymour M.; Martin, Pascal; Mascalchi, Mario; Moreira, José C.V.; Morita‐Sherman, Marcia E.; Pardoe, Heath R.; Pariente, Jose C.; Raviteja, Kotikalapudi; Rocha, Cristiane S.; Rodríguez‐Cruces, Raúl; Seeck, Margitta; Semmelroch, Mira K.H.G.; Sinclair, Benjamin; Soltanian‐Zadeh, Hamid; Stein, Dan J.; Striano, Pasquale; Taylor, Peter N.; Thomas, Rhys H.; Thomopoulos, Sophia I.; Velakoulis, Dennis; Vivash, Lucy; Weber, Bernd; Yasuda, Clarissa Lin; Zhang, Junsong; Thompson, Paul M.; McDonald, Carrie R.;
• Other Names: Abela Eugenio investigator.; Absil Julie investigator.; Adams Sophia investigator.; Alhusaini Saud investigator.; Alvim Marina investigator.; Balestrini Simona investigator.; Bender Benjamin investigator.; Bergo Felipe investigator.; Bernardes Tauana investigator.; Calvo Anna investigator.; Carreno Mar investigator.; Cherubini Andrea investigator.; David Philippe investigator.; Davoodi‐Bojd Esmaeil investigator.; Delanty Norman investigator.; Depondt Chantal investigator.; Devinsky Orrin investigator.; Doherty Colin investigator.; França Wendy Caroline investigator.; Franceschet Leticia investigator.; Hibar Derrek P. investigator.; Ishikawa Akari investigator.; Kaestner Erik investigator.; Langner Soenke investigator.; Liu Min investigator.; Mirandola Laura investigator.; Naylor Jillian investigator.; Nazem‐Zadeh Mohammad‐reza investigator.; O'Brien Terence J. investigator.; Ribeiro Letícia F. investigator.; Richardson Mark investigator.; Rosenow Felix investigator.; Severino Mariasavina investigator.; Shuai Chen investigator.; Tortora Domenico investigator.; von Podewils Felix investigator.; Vos Sjoerd B. investigator.; Wagner Jan investigator.; Zhang Guohao investigator.; Thompson P.M. guestEditor.; Jahanshad N. guestEditor.; Schmaal L. guestEditor.; Turner J.A. guestEditor.; Winkler A. guestEditor.; Thomopoulos S.I. guestEditor.; Egan G.F. guestEditor.; Kochunov P. guestEditor.;
• Is Part Of: Human brain mapping. Volume 43:Issue 1(2022)
• Page Start: 113
• Page End: 128
• Publication Date: 2020-05-29
• Subjects: covariance -- deep learning -- DTI -- event‐based modeling -- gene expression -- genetics -- imaging -- MRI -- quantitative -- rsfMRI; Brain mapping -- Periodicals; 611.81
• DOI: 10.1002/hbm.25037
• Languages: English
• ISSNs: 1065-9471

Abstract

Abstract: Epilepsy is a common and serious neurological disorder, with many different constituent conditions characterized by their electro clinical, imaging, and genetic features. MRI has been fundamental in advancing our understanding of brain processes in the epilepsies. Smaller‐scale studies have identified many interesting imaging phenomena, with implications both for understanding pathophysiology and improving clinical care. Through the infrastructure and concepts now well‐established by the ENIGMA Consortium, ENIGMA‐Epilepsy was established to strengthen epilepsy neuroscience by greatly increasing sample sizes, leveraging ideas and methods established in other ENIGMA projects, and generating a body of collaborating scientists and clinicians to drive forward robust research. Here we review published, current, and future projects, that include structural MRI, diffusion tensor imaging (DTI), and resting state functional MRI (rsfMRI), and that employ advanced methods including structural covariance, and event‐based modeling analysis. We explore age of onset‐ and duration‐related features, as well as phenomena‐specific work focusing on particular epilepsy syndromes or phenotypes, multimodal analyses focused on understanding the biology of disease progression, and deep learning approaches. We encourage groups who may be interested in participating to make contact to further grow and develop ENIGMA‐Epilepsy.