Tumor Associated Macrophages and TAMs‐Based Anti‐Tumor Nanomedicines. Issue 18 (22nd July 2021)

• Record Type: Journal Article
• Authors: Cheng, Yuxi; Song, Siyang; Wu, Peiyao; Lyu, Bochen; Qin, Mengmeng; Sun, Yanan; Sun, Aning; Mu, Limin; Xu, Fei; Zhang, Lu; Wang, Jiancheng; Zhang, Qiang
• Is Part Of: Advanced healthcare materials. Volume 10:Issue 18(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-07-22
• Subjects: anti‐tumor medicine -- cell carriers -- molecular mechanisms -- nanomedicines -- targeting -- tumor associated macrophages; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202100590
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: As an important part of tumor microenvironment, tumor associated macrophages (TAMs) play a vital role in the occurrence, development, invasion, and metastasis of many malignant tumors and can significantly promote the formation of tumor blood vessels and lymphatic vessels, hence TAMs are greatly associated with poor prognosis. The research on nanomedicine has achieved huge progress, and nano‐drugs have been widely utilized to treat various diseases through different mechanisms. Therefore, developing nano‐drugs that are based on TAMs‐associated anti‐tumor mechanisms to effectively suppress tumor growth is expected to be a promising research filed. This paper introduces relevant information about TAMs in terms of their origin, and their roles in tumor genesis, development and metastasis. Furthermore, TAMs‐related anti‐tumor nano‐drugs are summarized. Specifically, a wide range of nano‐drugs targeting at TAMs are introduced, and categorized according to their therapeutic mechanisms toward tumors. Additionally, various nano delivery platforms using TAMs as cell carriers which aim at inhibiting tumor growth are reviewed. These two parts elucidate that the exploration of nanomedicine is essential to the study on TAMs‐related anti‐tumor strategies. This review is also intended to provide novel ideas for in‐depth investigation on anti‐tumor molecular mechanisms and nano‐drug delivery systems based on TAMs. Abstract : This paper firstly generalizes various roles of tumor associated macrophages (TAMs) involved in the progression of cancers, and subsequently reviews anti‐tumor nanomedicines targeting TAMs by suppressing TAMs from being recruited to tumor sites, inhibiting viability of TAMs, inducing the reprogramming of TAMs into M1‐type or enhancing immune function of TAMs, and those using TAMs as cell‐carriers.