The Impact of a Hepatobiliary Multidisciplinary Team Assessment in Patients with Colorectal Cancer Liver Metastases: A Population‐Based Study. (26th May 2017)

• Record Type: Journal Article
• Authors: Engstrand, Jennie; Kartalis, Nikolaos; Strömberg, Cecilia; Broberg, Mats; Stillström, Anna; Lekberg, Tobias; Jonas, Eduard; Freedman, Jacob; Nilsson, Henrik
• Is Part Of: Oncologist. Volume 22:Number 9(2017)
• Page Start: 1067
• Page End: 1074
• Publication Date: 2017-05-26
• Subjects: Colorectal cancer -- Liver metastases -- Extrahepatic metastases -- Hepatobiliary multidisciplinary teams -- Imaging; Oncology -- Periodicals; Tumors -- Periodicals; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Oncology; Tumors; Neoplasms; Electronic journals; Periodicals; Periodicals; 616.994
• DOI: 10.1634/theoncologist.2017-0028
• Languages: English
• ISSNs: 1083-7159

Abstract

Abstract : Background: Assessing patients with colorectal cancer liver metastases (CRCLM) by a liver multidisciplinary team (MDT) results in higher resection rates and improved survival. The aim of this study was to evaluate the potentially improved resection rate in a defined cohort if all patients with CRCLM were evaluated by a liver MDT. Patients and Methods: A retrospective analysis of patients diagnosed with colorectal cancer during 2008 in the greater Stockholm region was conducted. All patients with liver metastases (LM), detected during 5‐year follow‐up, were re‐evaluated at a fictive liver MDT in which previous imaging studies, tumor characteristics, medical history, and patients' own treatment preferences were presented. Treatment decisions for each patient were compared to the original management. Odds ratios (ORs) and 95% confidence intervals were estimated for factors associated with referral to the liver MDT. Results: Of 272 patients diagnosed with LM, 102 patients were discussed at an original liver MDT and 69 patients were eventually resected. At the fictive liver MDT, a further 22 patients were considered as resectable/potentially resectable, none previously assessed by a hepatobiliary surgeon. Factors influencing referral to liver MDT were age (OR 3.12, 1.72–5.65), American Society of Anaesthesiologists (ASA) score (OR 0.34, 0.18–0.63; ASA 2 vs. ASA 3), and number of LM (OR 0.10, 0.04–0.22; 1–5 LM vs. >10 LM), while gender ( p = .194) and treatment at a teaching hospital ( p = .838) were not. Conclusion: A meaningful number of patients with liver metastases are not managed according to best available evidence and the potential for higher resection rates is substantial. Abstract : A retrospective analysis of patients with a diagnosis of colorectal cancer was conducted. Patients with liver metastases were re‐evaluated by a liver‐specific multidisciplinary team, and the resulting treatment decisions were compared with the original management. Improvement in resection rates were evaluated, and results are presented here.