Addendum to Tetrachloroethylene [BAT value documentation, 2018]. Issue 4 (13th November 2019)

• Record Type: Journal Article
• Authors: Bolt, H.M.; Drexler, H.; Hartwig, A.
• Is Part Of: MAK collection for occupational health and safety. Volume 4:Issue 4(2019)
• Page Start: 2312
• Page End: 2317
• Publication Date: 2019-11-13
• Subjects: tetrachloroethylene -- perchloroethylene -- occupational exposure -- biological tolerance value -- BAT value -- BLW -- toxicity; Biological monitoring -- Periodicals; Industrial toxicology -- Periodicals; Hazardous substances -- Periodicals; 615.902
• DOI: 10.1002/3527600418.bb12718e2319
• Languages: English
• ISSNs: 2509-2383

Abstract

Abstract: In 2017, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated tetrachloroethylene [127‐18‐4 ], considering tetrachloroethylene in blood to characterize the internal exposure at the workplace. Available publications are described in detail. The exposure equivalents for carcinogenic substances (EKA) of inhaled tetrachloroethylene and tetrachloroethylene in blood were confirmed and extended by recent data. The evaluation of the BAT value was based on the relationship between tetrachloroethylene uptake by inhalation at the MAK value and the corresponding concentration of tetrachloroethylene in blood. An eight‐hour exposure at the present MAK value of 10 ml tetrachloroethylene/m 3 correlates, 16 hours after exposure, with a mean tetrachloroethylene concentration in blood of approximately 200 µg/l. Hence, a BAT value of 200 µg tetrachloroethylene/l blood was evaluated. Sampling time is 16 hours after exposure.