How does the hydrophobic content of methacrylate ABA triblock copolymers affect polymersome formation?. Issue 15 (14th June 2021)

• Record Type: Journal Article
• Authors: Zhang, Xinmo; Contini, Claudia; Constantinou, Anna P.; Doutch, James J.; Georgiou, Theoni K.
• Is Part Of: Journal of polymer science. Volume 59:Issue 15(2021)
• Page Start: 1724
• Page End: 1731
• Publication Date: 2021-06-14
• Subjects: 2‐(diethylamino)ethyl methacrylate -- ABA triblock copolymers -- poly(ethylene glycol) methyl methacrylate -- polymersomes -- self‐assembly; Polymers -- Periodicals; Polymerization -- Periodicals; Polymerization; Polymers; Periodicals; 547.7
• DOI: 10.1002/pol.20210371
• Languages: English
• ISSNs: 2642-4150

Abstract

Abstract: Polymersomes are exciting self‐assembled structures with great potential in pharmaceutical applications. A systematic investigation of a novel series of methacrylate‐based polymersomes is reported in this study. Five well‐defined ABA triblock copolymers with A being based on tri(ethylene glycol) methyl methacrylate and B being based on 2‐(diethylamino)ethyl methacrylate (DMAEMA) were synthesized using a living polymerization method. The effect of the composition of the ABA triblock copolymers on the thickness of the hydrophobic membrane of the polymersomes and the release of a model drug is demonstrated. Abstract :