The cell cycle and differentiation as integrated processes: Cyclins and CDKs reciprocally regulate Sox and Notch to balance stem cell maintenance. (19th May 2021)

• Record Type: Journal Article
• Authors: Muhr, Jonas; Hagey, Daniel W.
• Is Part Of: BioEssays. Volume 43:Number 7(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-05-19
• Subjects: CDK -- cell cycle -- cyclin -- differentiation -- Notch -- Sox -- stem cell; Molecular biology -- Periodicals; Cytology -- Periodicals; Developmental biology -- Periodicals; 572.8
• DOI: 10.1002/bies.202000285
• Languages: English
• ISSNs: 0265-9247

Abstract

Abstract: Development and maintenance of diverse organ systems require context‐specific regulation of stem cell behaviour. We hypothesize that this is achieved via reciprocal regulation between the cell cycle machinery and differentiation factors. This idea is supported by the parallel evolutionary emergence of differentiation pathways, cell cycle components and complex multicellularity. In addition, the activities of different cell cycle phases have been found to bias cells towards stem cell maintenance or differentiation. Finally, several direct mechanistic links between these two processes have been established. Here, we focus on interactions between cyclin‐CDK complexes and differentiation regulators of the Notch pathway and Sox family of transcription factors within the context of pluripotent and neural stem cells. Thus, this hypothesis formalizes the links between these two processes as an integrated network. Since such factors are common to all stem cells, better understanding their interconnections will help to explain their behaviour in health and disease. Abstract : Development and maintenance of organs requires context‐specific regulation of stem cell activities. We hypothesize that these are dependent upon reciprocal interactions between the cell‐cycle machinery and regulators of stem cell differentiation. To support this, we discuss the mechanistic links between these processes, as well as their parallel evolution with multicellularity.