Atypical sulcal pattern in boys with attention‐deficit/hyperactivity disorder. Issue 13 (31st May 2021)

• Record Type: Journal Article
• Authors: Li, Xinwei; Wang, Wei; Wang, Panyu; Hao, Chenru; Li, Zhangyong
• Is Part Of: Human brain mapping. Volume 42:Issue 13(2021)
• Page Start: 4362
• Page End: 4371
• Publication Date: 2021-05-31
• Subjects: attention‐deficit/hyperactivity disorder -- brain development -- magnetic resonance imaging -- sulcal pattern -- sulcal pit; Brain mapping -- Periodicals; 611.81
• DOI: 10.1002/hbm.25552
• Languages: English
• ISSNs: 1065-9471

Abstract

Abstract: Neurodevelopmental disorders, such as attention‐deficit/hyperactivity disorder (ADHD), are often accompanied by disrupted cortical folding. We applied a quantitative sulcal pattern analysis technique using graph structures to study the atypical cortical folding at the lobar level in ADHD brains in this study. A total of 183 ADHD patients and 167 typical developmental controls matched according to age and gender were enrolled. We first constructed sulcal graphs at the brain lobar level and then investigated their similarity to the typical sulcal patterns. The within‐group variability and interhemispheric similarity in sulcal patterns were also compared between the ADHD and TDC groups. The results showed that, compared with controls, the left frontal, right parietal, and temporal lobes displayed altered similarities to the typical sulcal patterns in patients with ADHD. Moreover, the sulcal patterns in ADHD seem to be more heterogeneous than those in controls. The results also identified the disruption of the typical asymmetric sulcal patterns in the frontal lobe between the ADHD and control groups. Taken together, our results revealed the atypical sulcal pattern in boys with ADHD and provide new insights into the neuroanatomical mechanisms of ADHD. Abstract : We applied a quantitative sulcal pattern analysis technique using graph structures was applied to study the atypical cortical folding at the lobar level in attention‐deficit/hyperactivity disorder (ADHD) brains. And the results revealed the atypical sulcal pattern in boys with ADHD and provide new insights into the neuroanatomical mechanisms of ADHD.