Control of meiotic double-strand-break formation by ATM: local and global views. Issue 10 (19th May 2018)

• Record Type: Journal Article
• Authors: Lukaszewicz, Agnieszka; Lange, Julian; Keeney, Scott; Jasin, Maria
• Is Part Of: Cell cycle. Volume 17:Issue 10(2018)
• Page Start: 1155
• Page End: 1172
• Publication Date: 2018-05-19
• Subjects: Meiotic recombination -- DNA double-strand break -- ATM/Tel1 kinase; Cell cycle -- Periodicals; 571.84377
• DOI: 10.1080/15384101.2018.1464847
• Languages: English
• ISSNs: 1538-4101

Abstract

ABSTRACT: DNA double-strand breaks (DSBs) generated by the SPO11 protein initiate meiotic recombination, an essential process for successful chromosome segregation during gametogenesis. The activity of SPO11 is controlled by multiple factors and regulatory mechanisms, such that the number of DSBs is limited and DSBs form at distinct positions in the genome and at the right time. Loss of this control can affect genome integrity or cause meiotic arrest by mechanisms that are not fully understood. Here we focus on the DSB-responsive kinase ATM and its functions in regulating meiotic DSB numbers and distribution. We review the recently discovered roles of ATM in this context, discuss their evolutionary conservation, and examine future research perspectives.