Chondroitin sulfate-based nanoparticles for enhanced chemo-photodynamic therapy overcoming multidrug resistance and lung metastasis of breast cancer. (15th February 2021)

• Record Type: Journal Article
• Authors: Shi, Xiaoqun; Yang, Xiaoye; Liu, Mengyao; Wang, Rujuan; Qiu, Na; Liu, Yuanxiu; Yang, Haotong; Ji, Jianbo; Zhai, Guangxi
• Is Part Of: Carbohydrate polymers. Volume 254(2021)
• Publication Date: 2021-02-15
• Subjects: Multidrug resistance -- Chemo-photodynamic therapy -- Anti-metastasis -- Chemosensitizer -- Reactive oxygen species -- Chondroitin sulfate; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.117459
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Novel chondroitin sulfate-based nanoparticles (PTX/CQE NPs) were initially prepared. PTX/CQE NPs could exert enhanced chemo-photodynamic therapy in vitro and in vivo . PTX/CQE NPs exhibited in vivo MDR inhibition and anti-metastasis efficacy. Abstract: As a major therapeutic approach for cancer treatment, the effectiveness of chemotherapy is challenged by multidrug resistance (MDR). Herein, we fabricated novel redox-responsive, chondroitin sulfate-based nanoparticles that could simultaneously deliver quercetin (chemosensitizer), chlorin e6 (photosensitizer) and paclitaxel (chemotherapeutic agent) to exert enhanced chemo-photodynamic therapy for overcoming MDR and lung metastasis of breast cancer. In vitro cell study showed that nanoparticles down-regulated the expression of P-glycolprotein (P-gp) on MCF-7/ADR cells and thereby improved the anticancer efficacy of PTX against MCF-7/ADR cells. Moreover, NIR laser irradiation could induce nanoparticles to generate cellular reactive oxygen species (ROS), leading to mitochondrial membrane potential loss, and meanwhile facilitating lysosomal escape of drugs. Importantly, the novel nanoplatform exhibited effective in vivo MDR inhibition and anti-metastasis efficacy through enhanced chemo-photodynamic therapy. Thus, the study suggested that the multifunctional nanoplatform had good application prospect for effective breast cancer therapy.