Back Cover: Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling (Angew. Chem. Int. Ed. 25/2021). Issue 25 (19th April 2021)

• Record Type: Journal Article
• Authors: Wendt, Mathias; Bellavita, Rosa; Gerber, Alan; Efrém, Nina‐Louisa; van Ramshorst, Thirza; Pearce, Nicholas M.; Davey, Paul R. J.; Everard, Isabel; Vazquez‐Chantada, Mercedes; Chiarparin, Elisabetta; Grieco, Paolo; Hennig, Sven; Grossmann, Tom N.
• Is Part Of: Angewandte Chemie international edition. Volume 60:Issue 25(2021)
• Page Start: 14196
• Page End: 14196
• Publication Date: 2021-04-19
• Subjects: cell-penetrating peptides -- macrocycles -- peptidomimetics -- protein–protein interactions -- thioether crosslinks; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202104892
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Bicyclic peptidomimetics bind the transcriptional coactivator β‐catenin. A structure‐based design strategy has been applied to minimize a 52 amino acid binding motif into bicyclic 16‐mer β‐sheet mimetics. The biologically most active mimetic exhibits robust cellular uptake and inhibits Wnt signaling in a cell‐based assay, as reported by Tom N. Grossmann and co‐workers in their Research Article on page 13937 .