Prevalence and genetic aspects of deaf mutism in Shanghai. Issue 10 (October 1987)

• Record Type: Journal Article
• Authors: Hu, D N; Qiu, W Q; Wu, B T; Fang, L Z; Zhou, F; Gu, Y P; Zhang, Q H; Yan, J H
• Is Part Of: Journal of medical genetics. Volume 24:Issue 10(1987)
• Page Start: 589
• Page End: 592
• Publication Date: 1987-10
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.24.10.589
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : Two hundred and eighty-five cases of congenital deaf mutism were ascertained in a population of 483, 611 in Zhabei District in Shanghai. The prevalence was 0.059% (1:1697). Inherited cases accounted for 84.83% of all cases. The mode of inheritance was autosomal recessive with complete penetrance and heterogeneity (consisting of at least five different loci). The fitness was 77.63%, the coefficient of selection was 0.2237, the mutation rate was 1.119 x 10(-4) mutation/gamete, and no heterozygote advantage was proven.