Association of central obesity with hepatocellular carcinoma in patients with chronic hepatitis B receiving antiviral therapy. Issue 3 (22nd June 2021)

• Record Type: Journal Article
• Authors: Fan, Rong; Niu, Junqi; Ma, Hong; Xie, Qing; Cheng, Jun; Rao, Huiying; Dou, Xiaoguang; Xie, Jianping; Zhao, Wei; Peng, Jie; Gao, Zhiliang; Gao, Hongbo; Chen, Xinyue; Chen, Jinjun; Li, Qiang; Tang, Hong; Zhang, Zhengang; Ren, Hong; Cheng, Mingliang; Liang, Xieer; Zhu, Chaonan; Wei, Lai; Jia, Jidong; Sun, Jian; Hou, Jinlin
• Other Names: Zhang Wenhong investigator.; Chen Chengwei investigator.; Gao Yanhang investigator.; Liu Zhihong investigator.; Yin Xueru investigator.; Wang Maorong investigator.; Xia Qi investigator.; Mao Yimin investigator.; Li Wu investigator.; Gu Ye investigator.; Xie Desheng investigator.; Lin Shumei investigator.; Hu Jinhua investigator.; Shang Jia investigator.; Liu Huimin investigator.; Yu Yanyan investigator.; Gan Jianhe investigator.; Han Tao investigator.; Mi Yuqiang investigator.; Ao Feijian investigator.; Zhao Longfeng investigator.; Zhou Donghui investigator.; Yin Huafa investigator.; Zhou Jijun investigator.; Sun Aimin investigator.; Wang Hong investigator.; Ying Hao investigator.; Wang Gongchen investigator.; Jiang Yongfang investigator.
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 54:Issue 3(2021)
• Page Start: 329
• Page End: 338
• Publication Date: 2021-06-22
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.16469
• Languages: English
• ISSNs: 0269-2813

Abstract

Summary: Background: Obesity is typically associated with metabolic dysfunction, but its impact on hepatocellular carcinoma (HCC) remains unclear in patients with chronic hepatitis B (CHB). Aim: To study the effect of obesity on HCC development in patients with CHB receiving antiviral therapy. Methods: We included patients from a Chinese multicentre, prospective, observational, treated CHB cohort in this study. General obesity was evaluated by body‐mass index (BMI). Central obesity was evaluated by waist circumference, waist‐to‐hip ratio and waist‐to‐height ratio. Results: A total of 5754 nucleos(t)ide analogue treated patients were enrolled in the analysis. The 5‐year cumulative incidence of HCC was 2.9%. Waist‐to‐height ratio performed better in predicting HCC development than BMI, waist circumference or waist‐to‐hip ratio. Patients with central obesity (defined as waist‐to‐height ratio >0.5) had significantly higher 5‐year incidence of HCC than those without central obesity in the overall population (3.9% vs 2.1%, hazard ratio [HR]: 2.06, P = 0.0001) and 745 propensity score matched pairs (4.7% vs 2.3%, HR: 2.04, P = 0.026), respectively. Besides cirrhosis status and aMAP HCC risk score, central obesity was also independently associated with HCC risk (HR: 1.63, P = 0.013). Waist‐to‐height ratio gain within 1 year was associated with a significantly higher HCC risk with an adjusted HR value of 1.88 (95% confidence interval: 1.12‐3.13, P = 0.017). Conclusions: Central obesity, evaluated by the waist‐to‐height ratio, was associated with a twofold increase in HCC risk among CHB patients receiving antiviral treatment, highlighting the important role of abnormal metabolic function in the progression of liver disease. Abstract : Central obesity, evaluated by the waist‐to‐height ratio, was associated with a twofold increase in hepatocellular carcinoma risk among CHB patients receiving antiviral treatment, highlighting the important role of abnormal metabolic function in the progression of liver disease.