Breast Fibromatosis: Radiologic–Pathologic Correlation. Issue 5 (9th August 2021)

• Record Type: Journal Article
• Authors: Winkler, Nicole; Peterson, Michael; Factor, Rachel
• Is Part Of: Journal of breast imaging. Volume 3:Issue 5(2021)
• Page Start: 597
• Page End: 602
• Publication Date: 2021-08-09
• Subjects: fibromatosis -- desmoid -- radiologic–pathologic correlation; Breast -- Imaging -- Periodicals; Breast -- Cancer -- Diagnosis -- Periodicals; 616.994490
• DOI: 10.1093/jbi/wbab051
• Languages: English
• ISSNs: 2631-6110

Abstract

Abstract: Fibromatosis of the breast is a rare, benign locally infiltrative tumor without metastatic potential. Patients typically present with a painless, palpable, firm breast mass, which may be mobile or fixed to the pectoralis muscle. While some cases are related to familial mutations in the adenomatous polyposis coli ( APC ) gene, the majority are sporadic due to somatic mutations or prior injury to the breast tissue. On mammography, fibromatosis is typically seen as an irregular, dense, spiculated mass. US demonstrates a hypoechoic, irregular mass with indistinct margins. Fibromatosis is indistinguishable from breast cancer on imaging, and core biopsy is required for definitive diagnosis. Wide local excision is the historical standard for treatment; however, recurrence rates are high, and other emerging therapies are being explored. This article reviews the clinical features, imaging and histopathologic findings, along with brief overview of management.