Voluntary movements cause beta oscillations increase and broadband slope decrease in the subthalamic nucleus of parkinsonian patients. (20th March 2020)

• Record Type: Journal Article
• Authors: Belova, Elena M.; Semenova, Ulia; Gamaleya, Anna A.; Tomskiy, Alexey A.; Sedov, Alexey
• Is Part Of: European journal of neuroscience. Volume 53:Number 7(2021)
• Page Start: 2205
• Page End: 2213
• Publication Date: 2020-03-20
• Subjects: local field potentials -- movement -- Parkinson's disease -- subthalamic nucleus; Nervous system -- Periodicals; 612.8
• DOI: 10.1111/ejn.14715
• Languages: English
• ISSNs: 0953-816X

Abstract

Abstract: Periodic features of local field potentials (LFP) are extensively studied to establish the pathophysiological features contributing to Parkinson's disease (PD). Pathological LFP synchronization in the subthalamic nucleus (STN) was assumed to link with motor signs of PD. Commonly, the association between oscillations and clinical signs is studied while the patients are at rest. However, changes in LFPs during movement may reflect particular traits of motor processing in the basal ganglia under PD. Recently, the aperiodic 1/f broadband component of LFP spectra has attracted the attention of researchers because it may provide meaningful information about the neural activity in the brain. Here, we compared LFP signals in the STN of parkinsonian patients at rest and during hand movements occasionally followed by leg movements using two approaches, one of which accounts for the aperiodic features of LFP spectra. Using both methods, a significant increase was observed in synchronization in the low beta range during sequent leg but not hand movements. For either movement, there was a significant increase in gamma range synchronization using uncorrected power spectra and a significant decrease in the slope of the aperiodic component for the 1/f‐corrected method. These findings may support the claim that the 1/f slope possibly reflects the excitatory/inhibitory projections ratio in the recording site. Only the difference in the slope correlated significantly with motor signs of PD. These data show that the slope of aperiodic component may be a useful measure that is sensitive to the specific state and its changes in the brain. Abstract : Local field potentials (LFP) signals were studied in the STN of parkinsonian patients at rest and during voluntary hand and leg movements with raw PSD approach and a method that accounts for the aperiodic features of LFP spectra. Using both methods, a significant increase was observed in the low beta power during leg but not hand movements. For both movements, gamma power increased when using uncorrected power spectra and the slope of the aperiodic component decreased when using the novel method.