The influence of macro-textural designs over implant surface on bone on-growth: A computational mechanobiology based study. (September 2020)

• Record Type: Journal Article
• Authors: Ghosh, Rajdeep; Chanda, Souptick; Chakraborty, Debabrata
• Is Part Of: Computers in biology and medicine. Volume 124(2020)
• Publication Date: 2020-09
• Subjects: Uncemented implant -- Bone on-growth -- Macro-texture -- Mechanoregulation -- Micromotion -- Finite element analysis; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2020.103937
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: The longerterm secondary stability of an uncemented implant depends primarily on the quality and extent of bone in-growth or on-growth at the bone-implant interface. Investigations are warranted to predict the influences of implant macro-textures on bone on-growth pattern. Mechanoregulatory tissue differentiation algorithms can predict such patterns effectively. There is, however, a dearth of volumetric in silico study to assess the influence of macro-textures on bone growth. The present study investigated the influence of macro-textural grooves/ribs on changes in tissue formation at the bone-implant interface by carrying out a 3D finite element (FE) analysis. Three distinct macro-textures, loosely based on commercially viable hip stem models, were comparatively assessed for varying levels of interfacial micromotion. The study predicted elevated fibrogenesis and chondrogenesis, followed by a suppressed osteogenesis for higher levels of micromotion (60 μm and 100 μm), resulting in weak bone-implant interface strength. However, small judicious modifications in implant surface texture may enhance bone growth to a considerable extent. The numerical scheme can further be used as a template for more rigorous parametric and multi-scale studies. Highlights: Proposed mechanoregulatory scheme to study influence of macro-textures on tissue formation at the bone-implant interface. Three distinct macro-textures were comparatively evaluated for the quality and extent of bone on-growth. Enhanced fibrogenesis and chondrogenesis followed by a reduced osteogenesis was predicted under higher levels of micromotion. Judicious modifications in the surface geometry of uncemented implants may enhance bone formation to a considerable extent.