Exploring neutron capture therapy with 33S and 10B. (September 2020)

• Record Type: Journal Article
• Authors: López-Casas, I.; Praena, J.; Arias de Saavedra, F.; Sabaté-Gilarte, M.; Porras, I.
• Is Part Of: Applied radiation and isotopes. Volume 163(2020:Sep.)
• Publication Date: 2020-09
• Subjects: Neutron capture therapy -- Epithermal neutrons -- 33S as Neutron target -- Dose rate on tissue; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2020.109220
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: The 33 S(n, α) 30 Si reaction was proposed as cooperative neutron capturer to 10 B(n, α) 7 Li in Neutron Capture Therapy (NCT). At that moment, the available 33 S(n, α) 30 Si cross-section data were scarce and discrepant in key energy ranges for its use in NCT. Since then, three experiments have been carried out at n_TOF facility at CERN and at Institut Laue-Langevin. These new data are used for the calculation of the dose rate on ICRU-4 tissue by using kerma factors, a simplified model of tissue and a 13.45 keV neutron beam, energy of the most important 33 S(n, α) 30 Si resonance. A significant enhancement of the dose rate due to the presence of 33 S is shown. In spite of the limitations, the cooperative action of 33 S and 10 B is an interesting possibility to be studied for accelerator-based neutron sources with non-moderated neutrons. Highlights: 33 S as neutron capturer in BNCT. New data on the 33 S(n, α) 30 Si reaction. Simulations of the dose rate. Comparison between 10 B and 33 S and combined effect.