APPLICATION OF PERCUTANEOUS TRANSLUMINAL SEPTAL MYOCARDIAL ABLATION ON HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY. (8th October 2012)

• Record Type: Journal Article
• Authors: Yu, Wang; Hongming, Liu; Hongjie, Zhang; Tao, Guo
• Is Part Of: Heart. Volume 98(2012)Supplement 2
• Page Start: E250
• Page End: E250
• Publication Date: 2012-10-08
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2012-302920q.11
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objectives: To evaluate the feasibility and efficiency of percutaneous transluminal septal myocardial ablation (PTSMA) for treatment of hypertrophic obstructive cardiomyopathy (HOCM). Methods: Eleven patients with 1–10 years history of HOCM underwent the PTSMA. Left ventricular outflow tract gradient (LVOTG) were measured before and after septal branches occluded by 96%–99% alcohol. The thickness of septal myocardium, width of LVOT and amplitude of systolic anterior motion (SAM) were also measured before, at the time of discharge and 1 month after PTSMA by echocardiography. Results: Ten patients were accomplished by Sigwart method, among which, DDD pacemaker was implanted in one patient because of permanent complete heart block 5 days later. One patient died from acute myocardial infartion 4 h after ablation. Immediate post-operation, LVOTG decreased significantly from (90.40±41.95) mm Hg to (52.90±34.12) mm Hg (p<0.01). At the time of discharge, LVOTG and amplitude of SAM improved significantly (82.98±36.46 mm Hg vs 44.56±28.87 mm Hg; 4.1±1.37 mm Hg vs 2.3±1.06 mm Hg, p<0.01). At 1 month follow up, LVOTG, thickness of septal myocardium, width of LVOT and amplitude of SAM had a good direction to improvement (p<0.01). Conclusions: PTSMA can significantly reduce LVOTG and has a satisfactory short-term efficacy in the treatment of HOCM. Risk control must be emphasised during the ablation procedure and further careful evaluation is needed.