ASSOCIATION OF SOCS3 GENE POLYMORPHISMS WITH OVERWEIGHT AND OBESITY IN UYGUR POPULATION IN XINJIANG HETIAN AREA OF CHINA. (8th October 2012)

• Record Type: Journal Article
• Authors: Na, Lin; Xiao-guang, Yao; Ling, Zhou; Hong-mei, Wang; Jing, Hong; Nan-fang, Li; Nan-fang, Li
• Is Part Of: Heart. Volume 98(2012)Supplement 2
• Page Start: E156
• Page End: E156
• Publication Date: 2012-10-08
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2012-302920h.5
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objectives: To explore the relationship between suppressor of cytokine signalling 3 (SOCS3) genetic polymorphisms and overweight and obesity in Uygur Chinese general population in Xinjiang. Methods: 1407 Uygur individuals were enrolled (530 males, 876 females), The 3 single nucleotide polymorphisms (rs4949169, rs9914220, rs12953258) in SOCS3 gene were selected, Measure the height, weight, waist and hip circumference, calculate body mass index (BMI). Results: (1) Significant association was found between rs4949168 and the overweight, obesity in males, BMI (GG : AG : AA : (26.44±4.16) kg/m 2 vs (27.23±4.34) kg/m 2 vs (27.78±4.48) kg/m 2, p=0.042). Rs 991 4220 was associated with overweight and obesity in Uygur females in Xinjiang HETIAN area. But rs12953258 was not associated with overweight and obesity in Xinjiang HETIAN area. Conclusions: SOCS3 gene was significant associated with overweight and obesity in Uygur population in Xinjiang HETIAN area, and SOCS3 gene associated with overweight and obesity express distinctive in different gender.