Design of chitosan-based particle systems: A review of the physicochemical foundations for tailored properties. (15th December 2020)

• Record Type: Journal Article
• Authors: Ferreira, Leonardo M.B.; dos Santos, Aline M.; Boni, Fernanda Isadora; dos Santos, Karen C.; Robusti, Leda M. Gorla; de Souza, Maurício P.C.; Ferreira, Natália N.; Carvalho, Suzana G.; Cardoso, Valéria M.O.; Chorilli, Marlus; Cury, Beatriz S.F.; de Godoi, Denis R.M.; Gremião, Maria Palmira D.
• Is Part Of: Carbohydrate polymers. Volume 250(2020)
• Publication Date: 2020-12-15
• Subjects: TPP tripolyphosphate -- PLGA poly (lactic-co-glycolic-acid) -- CS chitosan -- LD50 lethal dose 50 % -- DDS drug delivery system -- Mw molecular weight -- DD deacetylation degree -- HMWC high molecular weight chitosan -- MMWC medium molecular weight chitosan -- LMWC low molecular weight chitosan -- COS chitosan oligosaccharides -- vdW van der Waals -- H-bond hydrogen bond -- EDL electrical double layer -- ZP zeta potential -- IG ionotropic gelation -- PdI polydispersity index -- DS dextran sulfate -- PECs polyelectrolyte complexes -- HA hyaluronic acid -- ALG alginate -- MTX methotrexate -- HP hypromellose phthalate -- FUC fucoidan -- PCT pectin -- XG xanthan gum -- GG gellan gum -- PVA poly (vinyl alcohol) -- LC lecithin; Chitosan particles -- Polysaccharides -- Supramolecular chemistry -- Thermodynamics -- Self-assembly -- Rational design; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.116968
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Thermodynamics and Supramolecular chemistry aid the design of chitosan particles. Bulk and Interfacial complexation of chitosan demand different design strategies. Initial polyelectrolyte solution properties can interfere in particle formation. EDL properties of polyelectrolyte solution is an important design parameter. Bridging theory and experiments fosters an improved control of particle properties. Abstract: Chitosan-based particles are widely proposed as biocompatible drug delivery systems with mucoadhesive and permeation enhancing properties. However, strategies on how to modulate the intended biological responses are still scarce. Considering that particle properties affect the biological outcome, the rational design of the synthesis variables should be proposed to engineer drug delivery systems with improved biological performance. The purpose of this review is to establish a deeper understanding of possible correlations between these variables and the particle properties from theoretical and experimental perspectives. The fundamental physicochemical knowledge of chitosan-based polyelectrolyte complexation and surface modification is discussed focusing on chitosan-TPP, polyelectrolyte complexes, and chitosan-surface modified PLGA or lipid particles. A set of design considerations is proposed to enable future investigation in the development of chitosan particles with modulated properties. The approach presented here contributes to the rational design of chitosan-based particles that meet different requirements for biological activities.