Impact of type II diabetes and gender on major clinical events after percutaneous coronary intervention. Issue 2 (April 2021)

• Record Type: Journal Article
• Authors: Sayadi, Mehrab; Zibaeenezhad, Mohammad Javad; Safaei, Khosrow; Elyaspour, Zahra; Verdecchia, Paolo; Razeghian-Jahromi, Iman
• Is Part Of: Primary care diabetes. Volume 15:Issue 2(2021)
• Page Start: 347
• Page End: 351
• Publication Date: 2021-04
• Subjects: Diabetes -- Coronary revascularization -- Cardiovascular events -- Gender; Diabetes -- Periodicals; 616.462
• DOI: 10.1016/j.pcd.2020.11.004
• Languages: English
• ISSNs: 1751-9918

Abstract

Highlights: There was a higher prevalence of hypertension and hyperlipidemia in women. There were no MACE events in the short term time-window. Diabetes had no impact on time-to-event neither in men, nor in women. MACE incidence was not different between men and women overall. Abstract: Aims: Incidence of type 2 diabetes is markedly rising worldwide. Some studies suggest that the occurrence of major adverse cardiac events (MACE) after PCI is different in men and women, but data are conflicting. Methods: We studied patients with stable coronary artery disease (CAD) who underwent PCI between years 2000 and 2017. Patients with primary PCI were excluded. Drug-eluting stent (DES) and dual antiplatelet therapy were administered in all patients. We followed these patients for a mean of 68 months. MACE as a composite of coronary revascularization, myocardial infarction or cardiovascular death was sought in three time windows. Results: We studied 1799 patients, 29.6% of whom with diabetes. Women were 52%. In multivariate analyses, there were no significant differences in the risk of MACE between diabetic and non-diabetic patients, as well as between men and women, neither in different time windows, nor in the whole duration of follow-up. The components of MACE did not show any significant differences between diabetic and non-diabetic patients, as well as between the genders. Conclusion: In our patients with stable CAD who received a modern therapeutic management after PCI, neither type 2 diabetes nor gender were associated with an excess risk of MACE.