Alexander's disease with Rosenthal fibre formation in an adult. Issue 4 (April 1984)

• Record Type: Journal Article
• Authors: Walls, T J; Jones, R A; Cartlidge, N; Saunders, M
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 47:Issue 4(1984)
• Page Start: 399
• Page End: 403
• Publication Date: 1984-04
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.47.4.399
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : The case of a woman who had a mild mental and physical handicap all her life is described. At the age of 39 years she began a progressive deterioration which terminated with her death after a year. CT scanning revealed basal ganglia calcification and at necropsy there was evidence of widespread generalised myelin loss with extensive Rosenthal fibre formation. The hypothesis that this may be an adult form of Alexander's disease is discussed.