An appraisal on synthetic and pharmaceutical perspectives of quinoxaline 1, 4‐di‐N‐oxide scaffold. (1st June 2022)

• Record Type: Journal Article
• Authors: Agrawal, Neetu; Bhardwaj, Aditya
• Is Part Of: Chemical biology & drug design. Volume 100:Number 3(2022)
• Page Start: 346
• Page End: 363
• Publication Date: 2022-06-01
• Subjects: anthelminthic -- anti‐chagasic agents -- antifungal agents -- antimalarial -- anti‐mycobacterial -- antitumor -- QdNO -- QdNO synthetic reactions -- quinoxaline -- quinoxaline 1, 4‐di‐N‐oxides; Drugs -- Design -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; 615.19005
• DOI: 10.1111/cbdd.14094
• Languages: English
• ISSNs: 1747-0277

Abstract

Abstract: Quinoxaline 1, 4‐di‐ N ‐oxides (QdNOs) exhibit multifaceted biological properties, wherein antimicrobial, anticancer, antitrypanosomal, and anti‐inflammatory properties are included. Because of their various activities in clinical practice and research, they have a wide spectrum of uses and possibilities. QdNOs have received a significant amount of attention, and research into their medicinal chemistry is still a part of experimental investigation and analytical studies. In this review, QdNOs are classified depending on their actions, which include antibacterial and anti‐mycobacterial, anticancer or antitumor, antimalarial, antifungal, and other activities. In a conclusion, it's important to base the development of novel synthetic techniques and the design of new QdNO derivatives on the most up‐to‐date knowledge gleaned from recent research. With the summarised structure–activity relationship of fascinating QdNOs, this review aims to provide insights into the developments in the chemistry and biological activity of QdNO derivatives. Abstract : The information on QdNO‐based heterocycles presented in this review will not only keep medicinal specialists up to date on recent discoveries of QdNO biological activities but will also encourage them to use this promising framework for the design of novel molecules for the benefit of humanity.