Molecular epidemiology of multidrug-resistant Acinetobacter baumannii isolates from hospitals in Myanmar. (September 2020)

• Record Type: Journal Article
• Authors: Tada, Tatsuya; Uchida, Hiroki; Hishinuma, Tomomi; Watanabe, Shin; Tohya, Mari; Kuwahara-Arai, Kyoko; Mya, San; Zan, Khin Nyein; Kirikae, Teruo; Tin, Htay Htay
• Is Part Of: Journal of global antimicrobial resistance. Volume 22(2020)
• Page Start: 122
• Page End: 125
• Publication Date: 2020-09
• Subjects: Multidrug-resistant Acinetobacter baumannii -- 16S rRNA methylase -- molecular epidemiology; Drug resistance -- Periodicals; Drug resistance -- Periodicals; Drug resistance; Periodicals; 616.9041
• DOI: 10.1016/j.jgar.2020.02.011
• Languages: English
• ISSNs: 2213-7165

Abstract

Highlights: Multidrug-resistant (MDR) Acinetobacter baumannii isolates were isolated in hospitals in Myanmar. The majority of the MDR isolates belonged to ST2. Of the all 38 MDR A. baumannii isolates, 5 harbored bla NDM-1, and 28 did armA or armA2 . This is the first report of molecular epidemiological analysis on MDR A. baumannii isolates in hospitals in Myanmar. Abstract: Objective: The aim of this study was to clarify the genetic and epidemiological properties of multidrug-resistant Acinetobacter baumannii in medical settings in Myanmar. Methods: A total of 45 A. baumannii clinical isolates were obtained in medical settings in Myanmar. The whole genomes were sequenced by a next generation sequencer, and the phylogenetic tree was constructed from single nucleotide polymorphism concatemers. Multilocus sequence types were deduced and drug resistance genes were identified. Results: Thirty-eight MDR Acinetobacter baumannii isolates were obtained from seven hospitals in Myanmar. The majority of MDR A. baumannii isolates belonged to ST2. Of the 38 isolates, 5 harbored bla NDM-1, and 28 did armA or armA2 Conclusions: A. baumannii ST2 producing 16S rRNA methylase ArmA has been spreading in medical settings in Myanmar.